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Vol 74, No 1 (2006)
ORIGINAL PAPERS
Published online: 2008-02-18
Submitted: 2013-02-22
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Maximal respiratory pressures and exercise tolerance in patients with COPD

Marta Maskey-Warzęchowska, Tadeusz Przybyłowski, Katarzyna Hildebrand, Katarzyna Wrotek, Joanna Wiwała, Justyna Kościuch, Ryszarda Chazan
Pneumonol Alergol Pol 2006;74(1):72-76.

open access

Vol 74, No 1 (2006)
ORIGINAL PAPERS
Published online: 2008-02-18
Submitted: 2013-02-22

Abstract

Many authors reported respiratory muscle function impairment in patients with chronic obstructive pulmonary disease (COPD). Impaired respiratory muscle function may contribute exercise intolerance which is frequently observed in this disease.
Aim of the study: was to determine the influence of respiratory muscle function on exercise capacity in patients with COPD.
Methods: 23 patients with stable COPD aged 62.7 ± 9.3 years (6F, 17M; mean post-bronchodilator FEV1 = 47.9 ± 12.4% value predicted) participated in the study. Exercise capacity was assessed by the six-minute walk test and the incremental cardiopulmonary exercise test (CPET) on a treadmill. Maximal respiratory pressures (PImax, PEmax) were evaluated before and directly after CPET.
Results: The mean peak oxygen uptake (VO2max) was 27.2 ± 6.1 mlO2/min/kg and the mean distance walked during the 6MWT was 569.4 ± 101.7 m. Both PImax and PEmax decreased significantly after maximal exercise (71.4 ± 23.0 vs. 63.6 ± 22.2 cm H2O, p = 0.001 and 124.9 ± 46.5 vs 112.3 ± 46.6 cm H2O, p = 0.02 respectively). No correlation between VO2max and the 6-minute walk distance and the maximal respiratory pressures was found. We observed a negative correlation between the 6-minute walk distance and the difference between the pre- and post CPET maximal inspiratory pressure.
Conclusions: respiratory muscle function is impaired in patients with COPD but this does not affect exercise performance. Exercise causes a decrease of the respiratory muscle strength.

Abstract

Many authors reported respiratory muscle function impairment in patients with chronic obstructive pulmonary disease (COPD). Impaired respiratory muscle function may contribute exercise intolerance which is frequently observed in this disease.
Aim of the study: was to determine the influence of respiratory muscle function on exercise capacity in patients with COPD.
Methods: 23 patients with stable COPD aged 62.7 ± 9.3 years (6F, 17M; mean post-bronchodilator FEV1 = 47.9 ± 12.4% value predicted) participated in the study. Exercise capacity was assessed by the six-minute walk test and the incremental cardiopulmonary exercise test (CPET) on a treadmill. Maximal respiratory pressures (PImax, PEmax) were evaluated before and directly after CPET.
Results: The mean peak oxygen uptake (VO2max) was 27.2 ± 6.1 mlO2/min/kg and the mean distance walked during the 6MWT was 569.4 ± 101.7 m. Both PImax and PEmax decreased significantly after maximal exercise (71.4 ± 23.0 vs. 63.6 ± 22.2 cm H2O, p = 0.001 and 124.9 ± 46.5 vs 112.3 ± 46.6 cm H2O, p = 0.02 respectively). No correlation between VO2max and the 6-minute walk distance and the maximal respiratory pressures was found. We observed a negative correlation between the 6-minute walk distance and the difference between the pre- and post CPET maximal inspiratory pressure.
Conclusions: respiratory muscle function is impaired in patients with COPD but this does not affect exercise performance. Exercise causes a decrease of the respiratory muscle strength.
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Keywords

COPD; respiratory muscles; respiratory pressures; exercise test

About this article
Title

Maximal respiratory pressures and exercise tolerance in patients with COPD

Journal

Advances in Respiratory Medicine

Issue

Vol 74, No 1 (2006)

Pages

72-76

Published online

2008-02-18

Bibliographic record

Pneumonol Alergol Pol 2006;74(1):72-76.

Keywords

COPD
respiratory muscles
respiratory pressures
exercise test

Authors

Marta Maskey-Warzęchowska
Tadeusz Przybyłowski
Katarzyna Hildebrand
Katarzyna Wrotek
Joanna Wiwała
Justyna Kościuch
Ryszarda Chazan

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