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The influence of 3 weeks therapy with continous positive airway pressure (nCPAP) on serum leptin and homocysteine concentration in patients with obstructive sleep apnea syndrom (OSAS)
open access
Abstract
The aim of this study was to evaluate an effect of 3 weeks nCPAP therapy on a serum leptin and homocysteine concentrations in patients with OSA.
Material and methods: The study group consisted of 48 male patients in the age x = 51, 2?7, 5 years old, OSA was diagnosed by polisomnographic study The leptin concentration was evaluated by RIA methods (HUMAN LEPTIN RIA KIT), the homocysteine concentration was evaluated by Axis Homocysteine EIA test. Patients were treated by nCPAP during 3 weeks. Only 29 patients were effectively treated for this time. The compliance was: 5.07 ± 1.81 h
Results: In the group of 29 patients the serum leptin and homocysteine concentration before and after treatment were 11,05 ± 5,59 ng/mL vs. 11,07 ± 7,16 ng/mL i 10,98 ± 2,79 μmol/L vs. 10,34 ± 2,99 μmol/L. In the all study group the statistical important correlation between leptin and AHI, mean and minimal saturation overnight, fibrinogeneconcentration, BMI, WHR, waist circumference, heart rate and between homocysteine and heart rate were observed.
Conclusions: 3 weeks therapy does not have any effect on leptin and homocysteine concentrations in the studied group of patients with OSA. Serum leptin concentration correlates with AHI, TMB90, as well as with mean and minimal saturation during a sleep. This indicates a potentially higher risk of cardiovascular diseases in the studied group.
Pneumonol. Alergol. Pol. 2006, 74, 63-67.
Abstract
The aim of this study was to evaluate an effect of 3 weeks nCPAP therapy on a serum leptin and homocysteine concentrations in patients with OSA.
Material and methods: The study group consisted of 48 male patients in the age x = 51, 2?7, 5 years old, OSA was diagnosed by polisomnographic study The leptin concentration was evaluated by RIA methods (HUMAN LEPTIN RIA KIT), the homocysteine concentration was evaluated by Axis Homocysteine EIA test. Patients were treated by nCPAP during 3 weeks. Only 29 patients were effectively treated for this time. The compliance was: 5.07 ± 1.81 h
Results: In the group of 29 patients the serum leptin and homocysteine concentration before and after treatment were 11,05 ± 5,59 ng/mL vs. 11,07 ± 7,16 ng/mL i 10,98 ± 2,79 μmol/L vs. 10,34 ± 2,99 μmol/L. In the all study group the statistical important correlation between leptin and AHI, mean and minimal saturation overnight, fibrinogeneconcentration, BMI, WHR, waist circumference, heart rate and between homocysteine and heart rate were observed.
Conclusions: 3 weeks therapy does not have any effect on leptin and homocysteine concentrations in the studied group of patients with OSA. Serum leptin concentration correlates with AHI, TMB90, as well as with mean and minimal saturation during a sleep. This indicates a potentially higher risk of cardiovascular diseases in the studied group.
Pneumonol. Alergol. Pol. 2006, 74, 63-67.
Keywords
OSA; nCPAP; leptin; homocysteine


Title
The influence of 3 weeks therapy with continous positive airway pressure (nCPAP) on serum leptin and homocysteine concentration in patients with obstructive sleep apnea syndrom (OSAS)
Journal
Advances in Respiratory Medicine
Issue
Article type
Research paper
Pages
63-67
Published online
2008-02-18
Bibliographic record
Pneumonol Alergol Pol 2006;74(1):63-67.
Keywords
OSA
nCPAP
leptin
homocysteine
Authors
Renata Rubinsztajn
Marta Kumor
Krzysztof Byśkiniewicz
Ryszarda Chazan