open access

Vol 74, No 1 (2006)
ORIGINAL PAPERS
Published online: 2008-02-18
Submitted: 2013-02-22
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The influence of 3 weeks therapy with continous positive airway pressure (nCPAP) on serum leptin and homocysteine concentration in patients with obstructive sleep apnea syndrom (OSAS)

Renata Rubinsztajn, Marta Kumor, Krzysztof Byśkiniewicz, Ryszarda Chazan
Pneumonol Alergol Pol 2006;74(1):63-67.

open access

Vol 74, No 1 (2006)
ORIGINAL PAPERS
Published online: 2008-02-18
Submitted: 2013-02-22

Abstract

Obstructive sleep apnea (OSA) is one of the most often sleep disturbance. Not treated patients have 2-3 times more risk for death because of the cardiovascular diseases. Leptin and homocysteine are the risk factors for cardiovascular diseases. Treatment by nCPAP has positive influence for health care and reduction of hypertension in this group.
The aim of this study was to evaluate an effect of 3 weeks nCPAP therapy on a serum leptin and homocysteine concentrations in patients with OSA.
Material and methods: The study group consisted of 48 male patients in the age x = 51, 2?7, 5 years old, OSA was diagnosed by polisomnographic study The leptin concentration was evaluated by RIA methods (HUMAN LEPTIN RIA KIT), the homocysteine concentration was evaluated by Axis Homocysteine EIA test. Patients were treated by nCPAP during 3 weeks. Only 29 patients were effectively treated for this time. The compliance was: 5.07 ± 1.81 h
Results: In the group of 29 patients the serum leptin and homocysteine concentration before and after treatment were 11,05 ± 5,59 ng/mL vs. 11,07 ± 7,16 ng/mL i 10,98 ± 2,79 μmol/L vs. 10,34 ± 2,99 μmol/L. In the all study group the statistical important correlation between leptin and AHI, mean and minimal saturation overnight, fibrinogeneconcentration, BMI, WHR, waist circumference, heart rate and between homocysteine and heart rate were observed.
Conclusions: 3 weeks therapy does not have any effect on leptin and homocysteine concentrations in the studied group of patients with OSA. Serum leptin concentration correlates with AHI, TMB90, as well as with mean and minimal saturation during a sleep. This indicates a potentially higher risk of cardiovascular diseases in the studied group.
Pneumonol. Alergol. Pol. 2006, 74, 63-67.

Abstract

Obstructive sleep apnea (OSA) is one of the most often sleep disturbance. Not treated patients have 2-3 times more risk for death because of the cardiovascular diseases. Leptin and homocysteine are the risk factors for cardiovascular diseases. Treatment by nCPAP has positive influence for health care and reduction of hypertension in this group.
The aim of this study was to evaluate an effect of 3 weeks nCPAP therapy on a serum leptin and homocysteine concentrations in patients with OSA.
Material and methods: The study group consisted of 48 male patients in the age x = 51, 2?7, 5 years old, OSA was diagnosed by polisomnographic study The leptin concentration was evaluated by RIA methods (HUMAN LEPTIN RIA KIT), the homocysteine concentration was evaluated by Axis Homocysteine EIA test. Patients were treated by nCPAP during 3 weeks. Only 29 patients were effectively treated for this time. The compliance was: 5.07 ± 1.81 h
Results: In the group of 29 patients the serum leptin and homocysteine concentration before and after treatment were 11,05 ± 5,59 ng/mL vs. 11,07 ± 7,16 ng/mL i 10,98 ± 2,79 μmol/L vs. 10,34 ± 2,99 μmol/L. In the all study group the statistical important correlation between leptin and AHI, mean and minimal saturation overnight, fibrinogeneconcentration, BMI, WHR, waist circumference, heart rate and between homocysteine and heart rate were observed.
Conclusions: 3 weeks therapy does not have any effect on leptin and homocysteine concentrations in the studied group of patients with OSA. Serum leptin concentration correlates with AHI, TMB90, as well as with mean and minimal saturation during a sleep. This indicates a potentially higher risk of cardiovascular diseases in the studied group.
Pneumonol. Alergol. Pol. 2006, 74, 63-67.
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Keywords

OSA; nCPAP; leptin; homocysteine

About this article
Title

The influence of 3 weeks therapy with continous positive airway pressure (nCPAP) on serum leptin and homocysteine concentration in patients with obstructive sleep apnea syndrom (OSAS)

Journal

Advances in Respiratory Medicine

Issue

Vol 74, No 1 (2006)

Pages

63-67

Published online

2008-02-18

Bibliographic record

Pneumonol Alergol Pol 2006;74(1):63-67.

Keywords

OSA
nCPAP
leptin
homocysteine

Authors

Renata Rubinsztajn
Marta Kumor
Krzysztof Byśkiniewicz
Ryszarda Chazan

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