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Influence of nasal continuous positive airway pressure on response to exercise in patients with obstructive sleep apnea syndrome
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Abstract
Methods: twenty nine OSAS patients (1 F, 28 M), mean age 50.7±9.7 yrs with body mass index of 32.6±4.5 kg/m2 participated in the study. OSAS was diagnosed by overnight polysomnography. Incremental cardiopulmonary exercise test (CPET) on a treadmill was performed twice: before and after 2-3 weeks of regular treatment with CPAP.
Results: mean apnea + hypopnea index (AHI) before therapy was 57.6±12 h-1. CPAP treatment did not change peak oxygen consumption (VO2max) (38.3±9.0 vs. 38.9±6.9 mlO2/kg/min, p=ns) or peak heart rate (153.4±21 min-1 vs. 155.5±22 min-1, p=ns). There were no significant changes in ventilation or gas exchange variables. However,a decrease in peak systolic blood pressure from 194.5±24 mm Hg to 186.7±27.9 mm Hg (p<0.05) with CPAP treatment was found. During recovery a decrease in heart rate (at 1st minute and minutes 3-6) and mean arterial pressure (MAP) (minutes 4-7) with CPAP treatment was observed. Significant correlations between VO2max and AHI (r=-0,38, p<0,05); MAP at peak exercise and: AHI, mean oxygen saturation (SaO2) during sleep, minutes of sleep with SaO2<90% (T90); MAP at recovery (minutes 3-8) and T90 before CPAP treatment were also noted.
Conclusions: OSAS patients are not limited on exercise. Treatment with nasal CPAP attenuates circulatory response to incremental exercise on a treadmill.
Pneumonol. Alergol. Pol. 2006, 74, 39-44.
Abstract
Methods: twenty nine OSAS patients (1 F, 28 M), mean age 50.7±9.7 yrs with body mass index of 32.6±4.5 kg/m2 participated in the study. OSAS was diagnosed by overnight polysomnography. Incremental cardiopulmonary exercise test (CPET) on a treadmill was performed twice: before and after 2-3 weeks of regular treatment with CPAP.
Results: mean apnea + hypopnea index (AHI) before therapy was 57.6±12 h-1. CPAP treatment did not change peak oxygen consumption (VO2max) (38.3±9.0 vs. 38.9±6.9 mlO2/kg/min, p=ns) or peak heart rate (153.4±21 min-1 vs. 155.5±22 min-1, p=ns). There were no significant changes in ventilation or gas exchange variables. However,a decrease in peak systolic blood pressure from 194.5±24 mm Hg to 186.7±27.9 mm Hg (p<0.05) with CPAP treatment was found. During recovery a decrease in heart rate (at 1st minute and minutes 3-6) and mean arterial pressure (MAP) (minutes 4-7) with CPAP treatment was observed. Significant correlations between VO2max and AHI (r=-0,38, p<0,05); MAP at peak exercise and: AHI, mean oxygen saturation (SaO2) during sleep, minutes of sleep with SaO2<90% (T90); MAP at recovery (minutes 3-8) and T90 before CPAP treatment were also noted.
Conclusions: OSAS patients are not limited on exercise. Treatment with nasal CPAP attenuates circulatory response to incremental exercise on a treadmill.
Pneumonol. Alergol. Pol. 2006, 74, 39-44.
Keywords
obstructive sleep apnea; stress test; polysomnography; CPAP
About this articleTitle
Influence of nasal continuous positive airway pressure on response to exercise in patients with obstructive sleep apnea syndrome
Journal
Advances in Respiratory Medicine
Issue
Pages
39-44
Published online
2008-02-18
Bibliographic record
Pneumonol Alergol Pol 2006;74(1):39-44.
Keywords
obstructive sleep apnea
stress test
polysomnography
CPAP
Authors
Tadeusz Przybyłowski
Piotr Bielecki
Marta Kumor
Katarzyna Hildebrand
Marta Maskey-Warzęchowska
Joanna Wiwała
Justyna Kościuch
Piotr Korczyński
Ryszarda Chazan