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Vol 74, No 1 (2006)
ORIGINAL PAPERS
Published online: 2008-02-18
Submitted: 2013-02-22
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Influence of nasal continuous positive airway pressure on response to exercise in patients with obstructive sleep apnea syndrome

Tadeusz Przybyłowski, Piotr Bielecki, Marta Kumor, Katarzyna Hildebrand, Marta Maskey-Warzęchowska, Joanna Wiwała, Justyna Kościuch, Piotr Korczyński, Ryszarda Chazan
Pneumonol Alergol Pol 2006;74(1):39-44.

open access

Vol 74, No 1 (2006)
ORIGINAL PAPERS
Published online: 2008-02-18
Submitted: 2013-02-22

Abstract

Obstructive sleep apnea syndrome (OSAS) patients are at risk of cardiovascular complications. The aim of this study was to assess the effect of treatment with continuous positive airway pressure (CPAP) on the response to symptom limited exercise test.
Methods: twenty nine OSAS patients (1 F, 28 M), mean age 50.7±9.7 yrs with body mass index of 32.6±4.5 kg/m2 participated in the study. OSAS was diagnosed by overnight polysomnography. Incremental cardiopulmonary exercise test (CPET) on a treadmill was performed twice: before and after 2-3 weeks of regular treatment with CPAP.
Results: mean apnea + hypopnea index (AHI) before therapy was 57.6±12 h-1. CPAP treatment did not change peak oxygen consumption (VO2max) (38.3±9.0 vs. 38.9±6.9 mlO2/kg/min, p=ns) or peak heart rate (153.4±21 min-1 vs. 155.5±22 min-1, p=ns). There were no significant changes in ventilation or gas exchange variables. However,a decrease in peak systolic blood pressure from 194.5±24 mm Hg to 186.7±27.9 mm Hg (p<0.05) with CPAP treatment was found. During recovery a decrease in heart rate (at 1st minute and minutes 3-6) and mean arterial pressure (MAP) (minutes 4-7) with CPAP treatment was observed. Significant correlations between VO2max and AHI (r=-0,38, p<0,05); MAP at peak exercise and: AHI, mean oxygen saturation (SaO2) during sleep, minutes of sleep with SaO2<90% (T90); MAP at recovery (minutes 3-8) and T90 before CPAP treatment were also noted.
Conclusions: OSAS patients are not limited on exercise. Treatment with nasal CPAP attenuates circulatory response to incremental exercise on a treadmill.
Pneumonol. Alergol. Pol. 2006, 74, 39-44.

Abstract

Obstructive sleep apnea syndrome (OSAS) patients are at risk of cardiovascular complications. The aim of this study was to assess the effect of treatment with continuous positive airway pressure (CPAP) on the response to symptom limited exercise test.
Methods: twenty nine OSAS patients (1 F, 28 M), mean age 50.7±9.7 yrs with body mass index of 32.6±4.5 kg/m2 participated in the study. OSAS was diagnosed by overnight polysomnography. Incremental cardiopulmonary exercise test (CPET) on a treadmill was performed twice: before and after 2-3 weeks of regular treatment with CPAP.
Results: mean apnea + hypopnea index (AHI) before therapy was 57.6±12 h-1. CPAP treatment did not change peak oxygen consumption (VO2max) (38.3±9.0 vs. 38.9±6.9 mlO2/kg/min, p=ns) or peak heart rate (153.4±21 min-1 vs. 155.5±22 min-1, p=ns). There were no significant changes in ventilation or gas exchange variables. However,a decrease in peak systolic blood pressure from 194.5±24 mm Hg to 186.7±27.9 mm Hg (p<0.05) with CPAP treatment was found. During recovery a decrease in heart rate (at 1st minute and minutes 3-6) and mean arterial pressure (MAP) (minutes 4-7) with CPAP treatment was observed. Significant correlations between VO2max and AHI (r=-0,38, p<0,05); MAP at peak exercise and: AHI, mean oxygen saturation (SaO2) during sleep, minutes of sleep with SaO2<90% (T90); MAP at recovery (minutes 3-8) and T90 before CPAP treatment were also noted.
Conclusions: OSAS patients are not limited on exercise. Treatment with nasal CPAP attenuates circulatory response to incremental exercise on a treadmill.
Pneumonol. Alergol. Pol. 2006, 74, 39-44.
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Keywords

obstructive sleep apnea; stress test; polysomnography; CPAP

About this article
Title

Influence of nasal continuous positive airway pressure on response to exercise in patients with obstructive sleep apnea syndrome

Journal

Advances in Respiratory Medicine

Issue

Vol 74, No 1 (2006)

Pages

39-44

Published online

2008-02-18

Bibliographic record

Pneumonol Alergol Pol 2006;74(1):39-44.

Keywords

obstructive sleep apnea
stress test
polysomnography
CPAP

Authors

Tadeusz Przybyłowski
Piotr Bielecki
Marta Kumor
Katarzyna Hildebrand
Marta Maskey-Warzęchowska
Joanna Wiwała
Justyna Kościuch
Piotr Korczyński
Ryszarda Chazan

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