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Influence of nasal continuous positive airway pressure on response to exercise in patients with obstructive sleep apnea syndrome
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Abstract
Methods: twenty nine OSAS patients (1 F, 28 M), mean age 50.7±9.7 yrs with body mass index of 32.6±4.5 kg/m2 participated in the study. OSAS was diagnosed by overnight polysomnography. Incremental cardiopulmonary exercise test (CPET) on a treadmill was performed twice: before and after 2-3 weeks of regular treatment with CPAP.
Results: mean apnea + hypopnea index (AHI) before therapy was 57.6±12 h-1. CPAP treatment did not change peak oxygen consumption (VO2max) (38.3±9.0 vs. 38.9±6.9 mlO2/kg/min, p=ns) or peak heart rate (153.4±21 min-1 vs. 155.5±22 min-1, p=ns). There were no significant changes in ventilation or gas exchange variables. However,a decrease in peak systolic blood pressure from 194.5±24 mm Hg to 186.7±27.9 mm Hg (p<0.05) with CPAP treatment was found. During recovery a decrease in heart rate (at 1st minute and minutes 3-6) and mean arterial pressure (MAP) (minutes 4-7) with CPAP treatment was observed. Significant correlations between VO2max and AHI (r=-0,38, p<0,05); MAP at peak exercise and: AHI, mean oxygen saturation (SaO2) during sleep, minutes of sleep with SaO2<90% (T90); MAP at recovery (minutes 3-8) and T90 before CPAP treatment were also noted.
Conclusions: OSAS patients are not limited on exercise. Treatment with nasal CPAP attenuates circulatory response to incremental exercise on a treadmill.
Pneumonol. Alergol. Pol. 2006, 74, 39-44.
Abstract
Methods: twenty nine OSAS patients (1 F, 28 M), mean age 50.7±9.7 yrs with body mass index of 32.6±4.5 kg/m2 participated in the study. OSAS was diagnosed by overnight polysomnography. Incremental cardiopulmonary exercise test (CPET) on a treadmill was performed twice: before and after 2-3 weeks of regular treatment with CPAP.
Results: mean apnea + hypopnea index (AHI) before therapy was 57.6±12 h-1. CPAP treatment did not change peak oxygen consumption (VO2max) (38.3±9.0 vs. 38.9±6.9 mlO2/kg/min, p=ns) or peak heart rate (153.4±21 min-1 vs. 155.5±22 min-1, p=ns). There were no significant changes in ventilation or gas exchange variables. However,a decrease in peak systolic blood pressure from 194.5±24 mm Hg to 186.7±27.9 mm Hg (p<0.05) with CPAP treatment was found. During recovery a decrease in heart rate (at 1st minute and minutes 3-6) and mean arterial pressure (MAP) (minutes 4-7) with CPAP treatment was observed. Significant correlations between VO2max and AHI (r=-0,38, p<0,05); MAP at peak exercise and: AHI, mean oxygen saturation (SaO2) during sleep, minutes of sleep with SaO2<90% (T90); MAP at recovery (minutes 3-8) and T90 before CPAP treatment were also noted.
Conclusions: OSAS patients are not limited on exercise. Treatment with nasal CPAP attenuates circulatory response to incremental exercise on a treadmill.
Pneumonol. Alergol. Pol. 2006, 74, 39-44.
Keywords
obstructive sleep apnea; stress test; polysomnography; CPAP
About this articleTitle
Influence of nasal continuous positive airway pressure on response to exercise in patients with obstructive sleep apnea syndrome
Journal
Advances in Respiratory Medicine
Issue
Article type
Research paper
Pages
39-44
Published online
2008-02-18
Bibliographic record
Pneumonol Alergol Pol 2006;74(1):39-44.
Keywords
obstructive sleep apnea
stress test
polysomnography
CPAP
Authors
Tadeusz Przybyłowski
Piotr Bielecki
Marta Kumor
Katarzyna Hildebrand
Marta Maskey-Warzęchowska
Joanna Wiwała
Justyna Kościuch
Piotr Korczyński
Ryszarda Chazan