open access

Vol 74, No 1 (2006)
ORIGINAL PAPERS
Published online: 2008-02-18
Submitted: 2013-02-22
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Influence of bronchoscopy on nitric oxide in exhaled air (FENO)

Katarzyna Hildebrand, Rafał Krenke, Tadeusz Przybyłowski, Adam Frangrat, Katarzyna Górska, Ryszarda Chazan
Pneumonol Alergol Pol 2006;74(1):26-31.

open access

Vol 74, No 1 (2006)
ORIGINAL PAPERS
Published online: 2008-02-18
Submitted: 2013-02-22

Abstract

Nitric oxide has been extensively studied as a noninvasive marker of airway inflammation,especiallyin asthma. Assuming, bronchoscopy can produced not only systemic but also local inflammatory response we hypothesized that bronchofiberoscopy can be responsible for an increase in nitric oxide synthesis with resulting increase in fractional concentration of exhaled nitric oxide (FENO).
Seventeen subjects (10 M, 7 F), at mean age of 53.8±14.1 yrs undergoing diagnostic bronchoscopy participated in the study. The indications for bronchoscopy were as follows: lung cancer (n=5; 29%), interstitial lung diseases (n=3; 18%), slowly resolving pneumonia (n=3; 18%), hemoptysis (n=3; 18%), differential diagnosis of asthma/dyspnea (n=3; 18%). During bronchoscopy bronchial washing (n=7) and bronchoalveolar lavage (BAL) (n=10) has been performed. FENO has been analyzed on-line with chemiluminescence analyzer (NIOX, Aerocrine, Sweden) according to American Thoracic Society guidelines, before and at 1, 2, 3 and 24 hours after bronchoscopy.
Mean FENO before bronchoscopy was 19.7±4.5 ppb (mean ± SEM), post - bronchoscopy a decrease with a nadir at second hour (12.1±1.5 ppb, p<0.05) was observed, FENO 24 hours after bronchoscopy was not different than baseline (18.4±2.5 ppb). There were no differences in the FENO profile in BAL patients when compared to those in whom only the bronchial washing has been performed.
Conclusions: Bronchoscopy leads to a significant decrease in exhaled nitric oxide. The underlying mechanisms are unclear. Future studies including analysis of other inflammatory markers are needed to explain these changes.
Pneumonol. Alergol. Pol. 2006, 74, 26-31.

Abstract

Nitric oxide has been extensively studied as a noninvasive marker of airway inflammation,especiallyin asthma. Assuming, bronchoscopy can produced not only systemic but also local inflammatory response we hypothesized that bronchofiberoscopy can be responsible for an increase in nitric oxide synthesis with resulting increase in fractional concentration of exhaled nitric oxide (FENO).
Seventeen subjects (10 M, 7 F), at mean age of 53.8±14.1 yrs undergoing diagnostic bronchoscopy participated in the study. The indications for bronchoscopy were as follows: lung cancer (n=5; 29%), interstitial lung diseases (n=3; 18%), slowly resolving pneumonia (n=3; 18%), hemoptysis (n=3; 18%), differential diagnosis of asthma/dyspnea (n=3; 18%). During bronchoscopy bronchial washing (n=7) and bronchoalveolar lavage (BAL) (n=10) has been performed. FENO has been analyzed on-line with chemiluminescence analyzer (NIOX, Aerocrine, Sweden) according to American Thoracic Society guidelines, before and at 1, 2, 3 and 24 hours after bronchoscopy.
Mean FENO before bronchoscopy was 19.7±4.5 ppb (mean ± SEM), post - bronchoscopy a decrease with a nadir at second hour (12.1±1.5 ppb, p<0.05) was observed, FENO 24 hours after bronchoscopy was not different than baseline (18.4±2.5 ppb). There were no differences in the FENO profile in BAL patients when compared to those in whom only the bronchial washing has been performed.
Conclusions: Bronchoscopy leads to a significant decrease in exhaled nitric oxide. The underlying mechanisms are unclear. Future studies including analysis of other inflammatory markers are needed to explain these changes.
Pneumonol. Alergol. Pol. 2006, 74, 26-31.
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Keywords

exhaled nitric oxide; bronchoscopy; bronchoalveolar lavage (BAL); inflammatory response

About this article
Title

Influence of bronchoscopy on nitric oxide in exhaled air (FENO)

Journal

Advances in Respiratory Medicine

Issue

Vol 74, No 1 (2006)

Pages

26-31

Published online

2008-02-18

Bibliographic record

Pneumonol Alergol Pol 2006;74(1):26-31.

Keywords

exhaled nitric oxide
bronchoscopy
bronchoalveolar lavage (BAL)
inflammatory response

Authors

Katarzyna Hildebrand
Rafał Krenke
Tadeusz Przybyłowski
Adam Frangrat
Katarzyna Górska
Ryszarda Chazan

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