open access

Vol 74, No 1 (2006)
ORIGINAL PAPERS
Published online: 2008-02-18
Submitted: 2013-02-22
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Exhaled nitric oxide in patients with obstructive sleep apnea syndrome

Tadeusz Przybyłowski, Piotr Bielicki, Marta Kumor, Katarzyna Hildebrand, Marta Maskey-Warzęchowska, Adam Frangrat, Katarzyna Górska, Piotr Korczyński, Ryszarda Chazan
Pneumonol Alergol Pol 2006;74(1):21-25.

open access

Vol 74, No 1 (2006)
ORIGINAL PAPERS
Published online: 2008-02-18
Submitted: 2013-02-22

Abstract

Exhaled nitric oxide has been extensively investigated as a non-invasive marker of airway inflammation. Some authors have suggested that morning FENO in obstructive sleep apnea syndrome (OSAS) patients is elevated due to inflammation of upper airways, while others have not found any differences between patients and healthy subjects. The purpose of this study was to analyze concentration of exhaled nitric oxide (FENO) in OSAS patients.
Methods: 119 (99 M, 20 F) consecutive patients of sleep laboratory participated in this study. Standard overnight sleep studies with polysomnography or portable screening device were carried out in the whole group: OSAS was diagnosed in 66 patients and 53 no-OSAS served as controls. FENO was measured on-line with a flow rate kept at 0.045-0.055 l/s, according to the recommendations of ATS using a chemiluminescence analyzer twice: before the sleep study (8-10 p.m.) and after termination of data collection (6-8 a.m.). There were no differences in age between patients and controls. Respiratory disturbance index (RDI) was 40.3±24.9 in patients and 3.7±2.8 in controls (p

Abstract

Exhaled nitric oxide has been extensively investigated as a non-invasive marker of airway inflammation. Some authors have suggested that morning FENO in obstructive sleep apnea syndrome (OSAS) patients is elevated due to inflammation of upper airways, while others have not found any differences between patients and healthy subjects. The purpose of this study was to analyze concentration of exhaled nitric oxide (FENO) in OSAS patients.
Methods: 119 (99 M, 20 F) consecutive patients of sleep laboratory participated in this study. Standard overnight sleep studies with polysomnography or portable screening device were carried out in the whole group: OSAS was diagnosed in 66 patients and 53 no-OSAS served as controls. FENO was measured on-line with a flow rate kept at 0.045-0.055 l/s, according to the recommendations of ATS using a chemiluminescence analyzer twice: before the sleep study (8-10 p.m.) and after termination of data collection (6-8 a.m.). There were no differences in age between patients and controls. Respiratory disturbance index (RDI) was 40.3±24.9 in patients and 3.7±2.8 in controls (p
Get Citation

Keywords

obstructive sleep apnea; exhaled nitric oxide; polysomnography

About this article
Title

Exhaled nitric oxide in patients with obstructive sleep apnea syndrome

Journal

Advances in Respiratory Medicine

Issue

Vol 74, No 1 (2006)

Pages

21-25

Published online

2008-02-18

Bibliographic record

Pneumonol Alergol Pol 2006;74(1):21-25.

Keywords

obstructive sleep apnea
exhaled nitric oxide
polysomnography

Authors

Tadeusz Przybyłowski
Piotr Bielicki
Marta Kumor
Katarzyna Hildebrand
Marta Maskey-Warzęchowska
Adam Frangrat
Katarzyna Górska
Piotr Korczyński
Ryszarda Chazan

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