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Exhaled nitric oxide in patients with obstructive sleep apnea syndrome
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Abstract
Methods: 119 (99 M, 20 F) consecutive patients of sleep laboratory participated in this study. Standard overnight sleep studies with polysomnography or portable screening device were carried out in the whole group: OSAS was diagnosed in 66 patients and 53 no-OSAS served as controls. FENO was measured on-line with a flow rate kept at 0.045-0.055 l/s, according to the recommendations of ATS using a chemiluminescence analyzer twice: before the sleep study (8-10 p.m.) and after termination of data collection (6-8 a.m.). There were no differences in age between patients and controls. Respiratory disturbance index (RDI) was 40.3±24.9 in patients and 3.7±2.8 in controls (p<0.001). In OSAS patients both evening and morning FENO was significantly higher compared to controls (23.1±14.8 ppb vs. 16.8±9.8 ppb and 22.4±13.2 ppb vs. 15.3±8.1 ppb respectively, p<0.05). Weak but statistically significant correlations for the whole group between morning FENO and mean and minimum arterial oxygen saturation (SaO2) during sleep and number of study minutes with SaO2<90% were observed. Lower evening FENO in OSAS patients with coexisting arterial hypertension when compared to normotensive OSAS patients was also noticed (19.1±10.8 ppb vs. 27.1±19.1 ppb; p<0.05).
Conclusions: The increase in FENO in OSAS patents may be caused by repetitive apneas and hypoxemia during sleep.
Pneumonol. Alergol. Pol. 2006, 74, 21-25.
Abstract
Methods: 119 (99 M, 20 F) consecutive patients of sleep laboratory participated in this study. Standard overnight sleep studies with polysomnography or portable screening device were carried out in the whole group: OSAS was diagnosed in 66 patients and 53 no-OSAS served as controls. FENO was measured on-line with a flow rate kept at 0.045-0.055 l/s, according to the recommendations of ATS using a chemiluminescence analyzer twice: before the sleep study (8-10 p.m.) and after termination of data collection (6-8 a.m.). There were no differences in age between patients and controls. Respiratory disturbance index (RDI) was 40.3±24.9 in patients and 3.7±2.8 in controls (p<0.001). In OSAS patients both evening and morning FENO was significantly higher compared to controls (23.1±14.8 ppb vs. 16.8±9.8 ppb and 22.4±13.2 ppb vs. 15.3±8.1 ppb respectively, p<0.05). Weak but statistically significant correlations for the whole group between morning FENO and mean and minimum arterial oxygen saturation (SaO2) during sleep and number of study minutes with SaO2<90% were observed. Lower evening FENO in OSAS patients with coexisting arterial hypertension when compared to normotensive OSAS patients was also noticed (19.1±10.8 ppb vs. 27.1±19.1 ppb; p<0.05).
Conclusions: The increase in FENO in OSAS patents may be caused by repetitive apneas and hypoxemia during sleep.
Pneumonol. Alergol. Pol. 2006, 74, 21-25.
Keywords
obstructive sleep apnea; exhaled nitric oxide; polysomnography
About this articleTitle
Exhaled nitric oxide in patients with obstructive sleep apnea syndrome
Journal
Advances in Respiratory Medicine
Issue
Article type
Research paper
Pages
21-25
Published online
2008-02-18
Bibliographic record
Pneumonol Alergol Pol 2006;74(1):21-25.
Keywords
obstructive sleep apnea
exhaled nitric oxide
polysomnography
Authors
Tadeusz Przybyłowski
Piotr Bielicki
Marta Kumor
Katarzyna Hildebrand
Marta Maskey-Warzęchowska
Adam Frangrat
Katarzyna Górska
Piotr Korczyński
Ryszarda Chazan