open access

Vol 74, No 4 (2006)
ORIGINAL PAPERS
Published online: 2006-09-08
Submitted: 2013-02-22
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Exacerbations of chronic obstructive pulmonary disease and the role of sputum bacteriological examination

Krzysztof Noweta, Mirosława Frankowska, Iwona Grzelewska-Rzymowska
Pneumonol Alergol Pol 2006;74(4):396-402.

open access

Vol 74, No 4 (2006)
ORIGINAL PAPERS
Published online: 2006-09-08
Submitted: 2013-02-22

Abstract

Bacteriological examination of sputum is the simplest and widely accessible diagnostic method of respiratory infections. However its value in nonspecific respiratory infections, especially in exacerbations of COPD, is questionable because they can be caused by factors other than bacterial or by viral infections.
The evaluation of bacteriological examination of sputum in patients with exacerbations of COPD and the evaluation of interaction between clinical course, some laboratory markers and bacteriology of sputum was the aim of the study.
109 patients hospitalized with exacerbations of COPD were examined. Semi-quantitative bacteriological examination of sputum, total blood count, erythrocytes sedimentation rate, gasometry and spirometry were performed in each patient. The identifi cation of pathogens was conducted by microtests API from Bio-Merieux.
In 39 patients (36%) pathogenic bacteria were cultured from sputum. The most prevalent organisms were: A. baumanii - 21% and S. aureus - 17%. Positive culture was seen most often in patients with severe and very severe COPD.
Bacterial infection as a cause of COPD exacerbation should be suspected especially in patients with severe-staged disease of long duration, when bacterial cells and predominant neutrophil-count are present in sputum. In patients with severe COPD, often treated in hospital and with antibiotics, Gram-negative flora should be considered as an etiologic agent.

Abstract

Bacteriological examination of sputum is the simplest and widely accessible diagnostic method of respiratory infections. However its value in nonspecific respiratory infections, especially in exacerbations of COPD, is questionable because they can be caused by factors other than bacterial or by viral infections.
The evaluation of bacteriological examination of sputum in patients with exacerbations of COPD and the evaluation of interaction between clinical course, some laboratory markers and bacteriology of sputum was the aim of the study.
109 patients hospitalized with exacerbations of COPD were examined. Semi-quantitative bacteriological examination of sputum, total blood count, erythrocytes sedimentation rate, gasometry and spirometry were performed in each patient. The identifi cation of pathogens was conducted by microtests API from Bio-Merieux.
In 39 patients (36%) pathogenic bacteria were cultured from sputum. The most prevalent organisms were: A. baumanii - 21% and S. aureus - 17%. Positive culture was seen most often in patients with severe and very severe COPD.
Bacterial infection as a cause of COPD exacerbation should be suspected especially in patients with severe-staged disease of long duration, when bacterial cells and predominant neutrophil-count are present in sputum. In patients with severe COPD, often treated in hospital and with antibiotics, Gram-negative flora should be considered as an etiologic agent.
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Keywords

exacerbation of COPD; bacteriological sputum examination; antibiotics

About this article
Title

Exacerbations of chronic obstructive pulmonary disease and the role of sputum bacteriological examination

Journal

Advances in Respiratory Medicine

Issue

Vol 74, No 4 (2006)

Pages

396-402

Published online

2006-09-08

Bibliographic record

Pneumonol Alergol Pol 2006;74(4):396-402.

Keywords

exacerbation of COPD
bacteriological sputum examination
antibiotics

Authors

Krzysztof Noweta
Mirosława Frankowska
Iwona Grzelewska-Rzymowska

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