open access

Vol 74, No 4 (2006)
ORIGINAL PAPERS
Published online: 2006-09-08
Submitted: 2013-02-22
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Serum and sputum eosinophil cationic protein levels and clinical status in cystic fi brosis patients

Aleksandra Korzeniewska, Anna Sołoniewicz, Piotr Stelmach, Agnieszka Sobocińska, Iwona Stelmach
Pneumonol Alergol Pol 2006;74(4):372-376.

open access

Vol 74, No 4 (2006)
ORIGINAL PAPERS
Published online: 2006-09-08
Submitted: 2013-02-22

Abstract

Recent studies have emphasied the role of eosinophils and it’s metabolites in the pathogenesis of lung disease in cystic fibrosis. This study was designed to assess the relationship between serum and sputum ECP levels and clinical status of cystic fibrosis patients.
Material and methods: 30 patients, aged 6-30 with moderate cystic fibrosis were recruited. Spirometry, weight and high, and Shwachman-Kulczycki score were measured, and serum and sputum samples were obtained for measurements of the eosinophil cationic protein (ECP).
Results: We observed significant inverse correlation between sputum ECP levels and BMI (p < 0.001) and FEV1 (p < 0.001), and not significant inverse correlation between sputum ECP levels Shwachman-Kulczycki score (p = 0.057). There was no signifi cant correlation between sputum ECP levels and FEF25/75% and between serum ECP levels and measured clinical parameters.
Conclusions: Results of this study suggest influence of eosinophil inflammation in respiratory tract on clinical status of CF patients.

Abstract

Recent studies have emphasied the role of eosinophils and it’s metabolites in the pathogenesis of lung disease in cystic fibrosis. This study was designed to assess the relationship between serum and sputum ECP levels and clinical status of cystic fibrosis patients.
Material and methods: 30 patients, aged 6-30 with moderate cystic fibrosis were recruited. Spirometry, weight and high, and Shwachman-Kulczycki score were measured, and serum and sputum samples were obtained for measurements of the eosinophil cationic protein (ECP).
Results: We observed significant inverse correlation between sputum ECP levels and BMI (p < 0.001) and FEV1 (p < 0.001), and not significant inverse correlation between sputum ECP levels Shwachman-Kulczycki score (p = 0.057). There was no signifi cant correlation between sputum ECP levels and FEF25/75% and between serum ECP levels and measured clinical parameters.
Conclusions: Results of this study suggest influence of eosinophil inflammation in respiratory tract on clinical status of CF patients.
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Keywords

eosinophil cationic protein; clinical status; cystic fibrosis

About this article
Title

Serum and sputum eosinophil cationic protein levels and clinical status in cystic fi brosis patients

Journal

Advances in Respiratory Medicine

Issue

Vol 74, No 4 (2006)

Pages

372-376

Published online

2006-09-08

Bibliographic record

Pneumonol Alergol Pol 2006;74(4):372-376.

Keywords

eosinophil cationic protein
clinical status
cystic fibrosis

Authors

Aleksandra Korzeniewska
Anna Sołoniewicz
Piotr Stelmach
Agnieszka Sobocińska
Iwona Stelmach

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