open access

Vol 75, No 1 (2007)
ORIGINAL PAPERS
Published online: 2007-04-13
Submitted: 2013-02-22

Tuberculosis caused by XDR resistant Mycobacterium tuberculosis in Poland. Microbiological and molecular analysis

Ewa Augustynowicz-Kopeć, Zofia Zwolska
Pneumonol Alergol Pol 2007;75(1):32-39.

open access

Vol 75, No 1 (2007)
ORIGINAL PAPERS
Published online: 2007-04-13
Submitted: 2013-02-22

Abstract


Introduction: The retrospective analysis of frequency of drug resistant tuberculosis XDR (XDR = MDR + resistance to: fluoroquinolones + amikacin and/or capreomycin) in Poland have been tested.
Material and methods: Pattern of resistance to first, second and third line drugs has been tested among new and treated patients. The total number of 10 913 Mycobacterium tuberculosis strains isolated from the same number of the patients surveyed in 1997-2004 in WHO programme Drug resistance surveillance countrywide study.
Results: One HIV-negative patient (43 years old men) was infected by XDR (0,4% among new and treated MDR cases). Molecular analysis of the XDR strain by spoligotyping has been shown the T11558 cluster. Three others tuberculosis patients living in the same region of Poland excreted the Mycobacterium tuberculosis strains belonged to the same T11558 cluster, but they had not pattern of XDR resistance. In the same T11558 molecular cluster 13/15 - 87% strains have been isolated from polish patients.
Conclusions: In Poland Mycobacterium tuberculosis resistance to fluoroquinolones, capreomycin and amikacine among MDR strains has been observed very rarely.

Keywords

tuberculosis; resistant tubercle bacilli; MDR; XDR; spoligotyping; Poland

About this article
Title

Tuberculosis caused by XDR resistant Mycobacterium tuberculosis in Poland. Microbiological and molecular analysis

Journal

Advances in Respiratory Medicine

Issue

Vol 75, No 1 (2007)

Pages

32-39

Published online

2007-04-13

Bibliographic record

Pneumonol Alergol Pol 2007;75(1):32-39.

Keywords

tuberculosis
resistant tubercle bacilli
MDR
XDR
spoligotyping
Poland

Authors

Ewa Augustynowicz-Kopeć
Zofia Zwolska

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Czasopismo Pneumonologia i Alergologia Polska dostęne jest również w Ikamed - księgarnia medyczna

Wydawcą serwisu jest "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl