open access

Vol 75, No 1 (2007)
ORIGINAL PAPERS
Published online: 2007-04-13
Submitted: 2013-02-22
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Transbronchial needle aspiration as a diagnostic method in lung cancer and non-malignant mediastinal adenopathy

Artur Szlubowski, Jarosław Kużdżał, Jerzy Soja, Ewa Łączyńska, Jolanta Hauer, Piotr Kopiński, Romana Tomaszewska, Marcin Zieliński
Pneumonol Alergol Pol 2007;75(1):5-12.

open access

Vol 75, No 1 (2007)
ORIGINAL PAPERS
Published online: 2007-04-13
Submitted: 2013-02-22

Abstract


Introduction: The aim of the study was to assess the diagnostic yield of transbronchial needle aspiration (TBNA) in mediastinal or hilar adenopathy in: lung cancer, staging of NSCLC, sarcoidosis and other non-malignant diseases.
Material and methods: Transbronchial needle aspiration was performed in 347 consecutive patients - 402 biopsies in groups of lymph nodes: subcarinal (7) - 179, all paratracheal (2R, 2L, 4R, 4L) - 168 and hilar (10R, 10L) - 55, with no real-time imaging guidance, preceded by computed tomography (CT), using 22-gauge needles. All negative results in NSCLC patients were verified by transcervical extended bilateral mediastinal lymphadenectomy (TEMLA) and the remaining patients underwent mediastinoscopy or thoracotomy.
Results: TBNA technique was diagnostic in 67.1% of lung cancer patients and in 59.0% of patients with sarcoidosis. In the group of all lung cancer patients specificity was 100%, sensitivity 88.5%, accuracy 91.8% and negative predictive value 77.9% and in diagnosing of lymph nodes involvement in NSCLC was respectively 100%, 86.6%, 90.7% and 76.6%. The high diagnostic yield was comparable for all mediastinal groups. In 80% of NSCLC patients with false negative results of TBNA there was observed partial involvement of metastatic lymph nodes, confirmed by TEMLA.
Conclusions: The diagnostic value of TBNA is very high in diagnostics of lung cancer, NSCLC staging and sarcoidosis but much lower in lymphomas, tuberculosis and other non-malignant diseases.

Abstract


Introduction: The aim of the study was to assess the diagnostic yield of transbronchial needle aspiration (TBNA) in mediastinal or hilar adenopathy in: lung cancer, staging of NSCLC, sarcoidosis and other non-malignant diseases.
Material and methods: Transbronchial needle aspiration was performed in 347 consecutive patients - 402 biopsies in groups of lymph nodes: subcarinal (7) - 179, all paratracheal (2R, 2L, 4R, 4L) - 168 and hilar (10R, 10L) - 55, with no real-time imaging guidance, preceded by computed tomography (CT), using 22-gauge needles. All negative results in NSCLC patients were verified by transcervical extended bilateral mediastinal lymphadenectomy (TEMLA) and the remaining patients underwent mediastinoscopy or thoracotomy.
Results: TBNA technique was diagnostic in 67.1% of lung cancer patients and in 59.0% of patients with sarcoidosis. In the group of all lung cancer patients specificity was 100%, sensitivity 88.5%, accuracy 91.8% and negative predictive value 77.9% and in diagnosing of lymph nodes involvement in NSCLC was respectively 100%, 86.6%, 90.7% and 76.6%. The high diagnostic yield was comparable for all mediastinal groups. In 80% of NSCLC patients with false negative results of TBNA there was observed partial involvement of metastatic lymph nodes, confirmed by TEMLA.
Conclusions: The diagnostic value of TBNA is very high in diagnostics of lung cancer, NSCLC staging and sarcoidosis but much lower in lymphomas, tuberculosis and other non-malignant diseases.
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Keywords

transbronchial needle aspiration; transcervical extended bilateral mediastinal lymphadenectomy; lung cancer; sarcoidosis

About this article
Title

Transbronchial needle aspiration as a diagnostic method in lung cancer and non-malignant mediastinal adenopathy

Journal

Advances in Respiratory Medicine

Issue

Vol 75, No 1 (2007)

Pages

5-12

Published online

2007-04-13

Bibliographic record

Pneumonol Alergol Pol 2007;75(1):5-12.

Keywords

transbronchial needle aspiration
transcervical extended bilateral mediastinal lymphadenectomy
lung cancer
sarcoidosis

Authors

Artur Szlubowski
Jarosław Kużdżał
Jerzy Soja
Ewa Łączyńska
Jolanta Hauer
Piotr Kopiński
Romana Tomaszewska
Marcin Zieliński

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