open access

Vol 75, No 3 (2007)
ORIGINAL PAPERS
Published online: 2007-07-30
Submitted: 2013-02-22
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Influence of flexible bronchoscopy on the concentration of exhaled nitric oxide

Grzegorz Kaczmarczyk, Dariusz Ziora, Jerzy Kozielski
Pneumonol Alergol Pol 2007;75(3):236-240.

open access

Vol 75, No 3 (2007)
ORIGINAL PAPERS
Published online: 2007-07-30
Submitted: 2013-02-22

Abstract

Introduction: Exhaled nitric oxide (eNO) is noninvasive parameter useful on estimation of airways inflammation, especially useful in monitoring of asthma inflammation. The aim of the study was estimation of bronchial tree inflammation after flexible bronchoscopy (FB) using eNO concentration.
Material and methods: In 41 patients (aged 29 to 74 yrs) eNO measurements using Sievers 280 Nitric Oxide Analyzer were performed before and 24 hours after FB. In control group (12 healthy persons aged 22 to 65 yrs) eNO measurements were also performed twice at 24 hours interval.
Results: In examined patients the mean eNO concentration before FB (15.0 ± 8.0 ppb) was significantly higher (p < 0.05) than in controls (6.9 ± 5.6 ppb). In examined patients we did not observe the significant changes in eNO after FB (15.0 ± 8.0 vs. 17.0 ± 7.9 ppb). The procedure of bronchial washing, bronchial brush or bronchial biopsy did not influence the results in examined patients. In control group the mean eNO results before and after 24 hours were similar (6.9 ± 5.6 ppb vs. 7.1 ± 5.9). The relative eNO changes after 24 hours of observation (decreases and increases), expressed as a per cent of parts per billion (% of ppb), were similar both in examined patients and controls.
Conclusions: BF and associated procedures does not influence on eNO concentration.

Abstract

Introduction: Exhaled nitric oxide (eNO) is noninvasive parameter useful on estimation of airways inflammation, especially useful in monitoring of asthma inflammation. The aim of the study was estimation of bronchial tree inflammation after flexible bronchoscopy (FB) using eNO concentration.
Material and methods: In 41 patients (aged 29 to 74 yrs) eNO measurements using Sievers 280 Nitric Oxide Analyzer were performed before and 24 hours after FB. In control group (12 healthy persons aged 22 to 65 yrs) eNO measurements were also performed twice at 24 hours interval.
Results: In examined patients the mean eNO concentration before FB (15.0 ± 8.0 ppb) was significantly higher (p < 0.05) than in controls (6.9 ± 5.6 ppb). In examined patients we did not observe the significant changes in eNO after FB (15.0 ± 8.0 vs. 17.0 ± 7.9 ppb). The procedure of bronchial washing, bronchial brush or bronchial biopsy did not influence the results in examined patients. In control group the mean eNO results before and after 24 hours were similar (6.9 ± 5.6 ppb vs. 7.1 ± 5.9). The relative eNO changes after 24 hours of observation (decreases and increases), expressed as a per cent of parts per billion (% of ppb), were similar both in examined patients and controls.
Conclusions: BF and associated procedures does not influence on eNO concentration.
Get Citation

Keywords

airways inflammation; nitric oxide; flexible bronchoscopy

About this article
Title

Influence of flexible bronchoscopy on the concentration of exhaled nitric oxide

Journal

Advances in Respiratory Medicine

Issue

Vol 75, No 3 (2007)

Pages

236-240

Published online

2007-07-30

Bibliographic record

Pneumonol Alergol Pol 2007;75(3):236-240.

Keywords

airways inflammation
nitric oxide
flexible bronchoscopy

Authors

Grzegorz Kaczmarczyk
Dariusz Ziora
Jerzy Kozielski

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