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Vol 75, No 4 (2007)
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Published online: 2007-10-26
Submitted: 2013-02-22
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Pathogenesis and clinical features of nonasthmatic eosinophilic bronchitis

Anna Dor-Wojnarowska, Bernard Panaszek
Pneumonol Alergol Pol 2007;75(4):389-393.

open access

Vol 75, No 4 (2007)
REVIEWS
Published online: 2007-10-26
Submitted: 2013-02-22

Abstract

The introduction of induced sputum, as the diagnostic and research tool allowed to define nonasthmatic eosinophilic bronchitis characterized as a chronic cough in patients with no symptoms or objective evidence of variable airflow obstruction, with normal airway hyperresponsiveness and sputum eosinophilia. Eosinophilic bronchitis is an important cause of chronic cough. Studies in which the assessment of airway inflammation has been undertaken in chronic cough patients have shown that nonasthmatic eosinophilic bronchitis accounts for 10 to 30% of cases referred for specialist investigation. Eosinophilic bronchitis, like asthma, is characterized by eosinophilic airway inflammation, but unlike asthma, there is no airway hyperresponsiveness or bronchoconstriction. The airway immunopathology of asthma and eosinophilic bronchitis are almost identical. An obvious question is why an apparently similar pattern of airway inflammation is associated with different functional abnormalities in patients with nonasthmatic eosinophilic bronchitis and asthma. The differences in functional association may be related to differences in the localization of mast cells within the airway wall, with airway smooth muscle infiltration occurring in patients with asthma, and epithelial infiltration in patients with nonasthmatic eosinophilic bronchitis.

Abstract

The introduction of induced sputum, as the diagnostic and research tool allowed to define nonasthmatic eosinophilic bronchitis characterized as a chronic cough in patients with no symptoms or objective evidence of variable airflow obstruction, with normal airway hyperresponsiveness and sputum eosinophilia. Eosinophilic bronchitis is an important cause of chronic cough. Studies in which the assessment of airway inflammation has been undertaken in chronic cough patients have shown that nonasthmatic eosinophilic bronchitis accounts for 10 to 30% of cases referred for specialist investigation. Eosinophilic bronchitis, like asthma, is characterized by eosinophilic airway inflammation, but unlike asthma, there is no airway hyperresponsiveness or bronchoconstriction. The airway immunopathology of asthma and eosinophilic bronchitis are almost identical. An obvious question is why an apparently similar pattern of airway inflammation is associated with different functional abnormalities in patients with nonasthmatic eosinophilic bronchitis and asthma. The differences in functional association may be related to differences in the localization of mast cells within the airway wall, with airway smooth muscle infiltration occurring in patients with asthma, and epithelial infiltration in patients with nonasthmatic eosinophilic bronchitis.
Citation Formats

Keywords

eosinophilic bronchitis; chronic cough; asthma

About this article
Title

Pathogenesis and clinical features of nonasthmatic eosinophilic bronchitis

Journal

Advances in Respiratory Medicine

Issue

Vol 75, No 4 (2007)

Pages

389-393

Published online

2007-10-26

Bibliographic record

Pneumonol Alergol Pol 2007;75(4):389-393.

Keywords

eosinophilic bronchitis
chronic cough
asthma

Authors

Anna Dor-Wojnarowska
Bernard Panaszek

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