open access

Vol 75, No 4 (2007)
REVIEWS
Published online: 2007-10-26
Submitted: 2013-02-22
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Histone dependent signalization during pharmacotherapy of chronic obstructive pulmonary disease

Robert Marek Mróz, Jacek Noparlik, Elżbieta Chyczewska, Jan Józef Braszko, Adam Hołownia
Pneumonol Alergol Pol 2007;75(4):375-382.

open access

Vol 75, No 4 (2007)
REVIEWS
Published online: 2007-10-26
Submitted: 2013-02-22

Abstract

Chronic obstructive pulmonary disease (COPD) is a 4th major cause of morbidity and mortality worldwide. Cigarette smoking and oxidative/nitrosative stress leading to chronic inflammation is considered as a major cause of COPD but up to now, details of molecular pathways responsible for development of disease are unknown. Recent reports indicate the role of disruption in histone function in promoting synthesis of inflammatory cytokines through increased gene transcription which underlies disease development. Core histone acetylation/deacetylation regulate their transcription activity and drug induced changes of its intensity may be an interesting field of further research. In this article the opinions about the role of steroids as inhibitors of the inflammatory process as well as resistance to steroids have been presented. Findings from studies which aimed to explore the anti-inflammatory activity of drugs such as theophylline and N-acetylcysteine and their ability to suppress oxidative stress may suggest the usefullness of these drugs in causative treatment of COPD. However, further studies are necessary to confirm these findings.

Abstract

Chronic obstructive pulmonary disease (COPD) is a 4th major cause of morbidity and mortality worldwide. Cigarette smoking and oxidative/nitrosative stress leading to chronic inflammation is considered as a major cause of COPD but up to now, details of molecular pathways responsible for development of disease are unknown. Recent reports indicate the role of disruption in histone function in promoting synthesis of inflammatory cytokines through increased gene transcription which underlies disease development. Core histone acetylation/deacetylation regulate their transcription activity and drug induced changes of its intensity may be an interesting field of further research. In this article the opinions about the role of steroids as inhibitors of the inflammatory process as well as resistance to steroids have been presented. Findings from studies which aimed to explore the anti-inflammatory activity of drugs such as theophylline and N-acetylcysteine and their ability to suppress oxidative stress may suggest the usefullness of these drugs in causative treatment of COPD. However, further studies are necessary to confirm these findings.
Get Citation

Keywords

COPD; histones; HDAC; theophyline; corticosteroids; N-acetylcysteine

About this article
Title

Histone dependent signalization during pharmacotherapy of chronic obstructive pulmonary disease

Journal

Advances in Respiratory Medicine

Issue

Vol 75, No 4 (2007)

Pages

375-382

Published online

2007-10-26

Bibliographic record

Pneumonol Alergol Pol 2007;75(4):375-382.

Keywords

COPD
histones
HDAC
theophyline
corticosteroids
N-acetylcysteine

Authors

Robert Marek Mróz
Jacek Noparlik
Elżbieta Chyczewska
Jan Józef Braszko
Adam Hołownia

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