open access

Vol 75, No 4 (2007)
ORIGINAL PAPERS
Published online: 2007-10-26
Submitted: 2013-02-22
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The variability of peak inspiratory flow (PIF) on valves imitating dry powder inhalers resistance during asthma and COPD exacerbations

Marcin Grabowski, Wojciech Barg, Beata Chmielowicz, Agnieszka Kopeć, Bernard Panaszek
Pneumonol Alergol Pol 2007;75(4):324-330.

open access

Vol 75, No 4 (2007)
ORIGINAL PAPERS
Published online: 2007-10-26
Submitted: 2013-02-22

Abstract

Introduction: Drugs used in asthma or COPD exacerbation are delivered to the lungs by inhalation. This is facilitated, among other factors, by the use of dry powder inhalers (DPIs). Lung deposition from DPI depends predominantly on peak inspiratory flow (PIF). The aim of the study was to asses the variability of PIF generated by patients using different types of DPI inhalers during asthma or COPD exacerbation and to trace possible relationships between PIF value and some spirometric values.
Material and methods: There were 28 patient fulfilling inclusion criteria, among them 17 (4 women) were suffering from COPD and 11 (8 women) from asthma. Spirometry, PEF and PIF measurements were performed in the first and the last day of hospitalisation. Peek inspiratory flow was obtained using In-Check DIAL - a device which simulated airflow resistances equivalent to Turbuhaler, Diskus and Aeroliser respectively.
Results: The significant improvement in PIF was observed only in patients with COPD. There were no statistically significant correlations between PIF and both FEV1 and PEF except those in the first day of hospitalization in COPD patients (r = 0.66-0.81). Optimal PIF was achieved in all patients only with Diskus.
Conclusions: Measurements of peek inspiratory flow are useful in choosing the most suitable DPI for patients with COPD and asthma exacerbations. We conclude that in those patients, PIF measurement should complement a standard spirometry.

Abstract

Introduction: Drugs used in asthma or COPD exacerbation are delivered to the lungs by inhalation. This is facilitated, among other factors, by the use of dry powder inhalers (DPIs). Lung deposition from DPI depends predominantly on peak inspiratory flow (PIF). The aim of the study was to asses the variability of PIF generated by patients using different types of DPI inhalers during asthma or COPD exacerbation and to trace possible relationships between PIF value and some spirometric values.
Material and methods: There were 28 patient fulfilling inclusion criteria, among them 17 (4 women) were suffering from COPD and 11 (8 women) from asthma. Spirometry, PEF and PIF measurements were performed in the first and the last day of hospitalisation. Peek inspiratory flow was obtained using In-Check DIAL - a device which simulated airflow resistances equivalent to Turbuhaler, Diskus and Aeroliser respectively.
Results: The significant improvement in PIF was observed only in patients with COPD. There were no statistically significant correlations between PIF and both FEV1 and PEF except those in the first day of hospitalization in COPD patients (r = 0.66-0.81). Optimal PIF was achieved in all patients only with Diskus.
Conclusions: Measurements of peek inspiratory flow are useful in choosing the most suitable DPI for patients with COPD and asthma exacerbations. We conclude that in those patients, PIF measurement should complement a standard spirometry.
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Keywords

peek inspiratory flow; Diskus; Turbuhaler; Aerolizer; exacerbation of asthma and COPD

About this article
Title

The variability of peak inspiratory flow (PIF) on valves imitating dry powder inhalers resistance during asthma and COPD exacerbations

Journal

Advances in Respiratory Medicine

Issue

Vol 75, No 4 (2007)

Pages

324-330

Published online

2007-10-26

Bibliographic record

Pneumonol Alergol Pol 2007;75(4):324-330.

Keywords

peek inspiratory flow
Diskus
Turbuhaler
Aerolizer
exacerbation of asthma and COPD

Authors

Marcin Grabowski
Wojciech Barg
Beata Chmielowicz
Agnieszka Kopeć
Bernard Panaszek

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