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open access

Vol 76, No 2 (2008)
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Published online: 2008-04-28
Submitted: 2013-02-22
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Role of immune system in the pathomechanism of obstructive sleep apnea

Joanna Chorostowska-Wynimko, Marta E. Kędzior
Pneumonol Alergol Pol 2008;76(2):101-110.

open access

Vol 76, No 2 (2008)
REVIEWS
Published online: 2008-04-28
Submitted: 2013-02-22

Abstract

Immune system plays an essential role in the pathomechanism of obstructive sleep apnea syndrome (OSA), in the development of certain OSA complications, like the increased risk of cardiovascular diseases. Indeed, it is the sleep fragmentation and chronic intermittent hypoxia/reoxygenation, that stimulates increased immunoreactivity and chronic inflammatory response, both systemic and local in the upper airways. This review summarizes current evidence on the most important regulatory mechanisms involving immune cells and mediators.

Abstract

Immune system plays an essential role in the pathomechanism of obstructive sleep apnea syndrome (OSA), in the development of certain OSA complications, like the increased risk of cardiovascular diseases. Indeed, it is the sleep fragmentation and chronic intermittent hypoxia/reoxygenation, that stimulates increased immunoreactivity and chronic inflammatory response, both systemic and local in the upper airways. This review summarizes current evidence on the most important regulatory mechanisms involving immune cells and mediators.

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Keywords

obstructive sleep apnea; intermittent hypoxia; immune system; chronic inflammation; cytokines

About this article
Title

Role of immune system in the pathomechanism of obstructive sleep apnea

Journal

Advances in Respiratory Medicine

Issue

Vol 76, No 2 (2008)

Pages

101-110

Published online

2008-04-28

Bibliographic record

Pneumonol Alergol Pol 2008;76(2):101-110.

Keywords

obstructive sleep apnea
intermittent hypoxia
immune system
chronic inflammation
cytokines

Authors

Joanna Chorostowska-Wynimko
Marta E. Kędzior

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