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Vol 76, No 2 (2008)
CASE REPORTS
Published online: 2008-04-28
Submitted: 2013-02-22
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Interstitial pneumonitis in a patient treated with amiodarone - case report

Anna Paczek, Monika Szturmowicz, Elżbieta Wiatr, Barbara Burakowska, Anna Fijałkowska, Adam Torbicki
Pneumonol Alergol Pol 2008;76(2):118-124.

open access

Vol 76, No 2 (2008)
CASE REPORTS
Published online: 2008-04-28
Submitted: 2013-02-22

Abstract

Amiodarone, antiarrhythmic drug of III class is used in patients with supraventricular and ventricular arrhythmias, often with coexisting congestive heart failure. Side effects of amiodarone treatment are observed in approximately 75% of patients. Most dangerous are the symptoms of amiodarone pulmonary toxicity occuring in 2-17% of patients. We present a patient with COPD, in whom interstitial pneumonitis with radiologic features of organizing pneumonia developed after one year of amiodaron treatment due to supraventricular and ventricular arrhythmias. The drug was stopped and steroids were introduced due to marked respiratory insufficiency. Regression of pulmonary symptoms and improvement of ventilatory parameters were observed after 3 months of treatment. Pathogenesis, diagnostic procedures and current methods of treatment of this jatrogenic disease are discussed.

Abstract

Amiodarone, antiarrhythmic drug of III class is used in patients with supraventricular and ventricular arrhythmias, often with coexisting congestive heart failure. Side effects of amiodarone treatment are observed in approximately 75% of patients. Most dangerous are the symptoms of amiodarone pulmonary toxicity occuring in 2-17% of patients. We present a patient with COPD, in whom interstitial pneumonitis with radiologic features of organizing pneumonia developed after one year of amiodaron treatment due to supraventricular and ventricular arrhythmias. The drug was stopped and steroids were introduced due to marked respiratory insufficiency. Regression of pulmonary symptoms and improvement of ventilatory parameters were observed after 3 months of treatment. Pathogenesis, diagnostic procedures and current methods of treatment of this jatrogenic disease are discussed.

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Keywords

amiodarone; organizing pneumonia; steroidotherapy

About this article
Title

Interstitial pneumonitis in a patient treated with amiodarone - case report

Journal

Advances in Respiratory Medicine

Issue

Vol 76, No 2 (2008)

Pages

118-124

Published online

2008-04-28

Bibliographic record

Pneumonol Alergol Pol 2008;76(2):118-124.

Keywords

amiodarone
organizing pneumonia
steroidotherapy

Authors

Anna Paczek
Monika Szturmowicz
Elżbieta Wiatr
Barbara Burakowska
Anna Fijałkowska
Adam Torbicki

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