open access

Vol 76, No 4 (2008)
ORIGINAL PAPERS
Published online: 2008-06-22
Submitted: 2013-02-22
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Protein C system in patients with idiopathic pulmonary fibrosis - preliminary report

Anna Kiziewicz, Ewa Żekanowska, Krzysztof Cieśliński, Krzysztof Góralczyk
Pneumonol Alergol Pol 2008;76(4):225-228.

open access

Vol 76, No 4 (2008)
ORIGINAL PAPERS
Published online: 2008-06-22
Submitted: 2013-02-22

Abstract

Introduction: The natural anticoagulant - activated protein C system plays an important role in the pathogenesis of idiopathic pulmonary fibrosis. The purpose of this study was to evaluate the concentration of protein C (PC), protein S (PS), thrombomodulin (TM), selectin E (sSelE), and thrombin–antithrombin complex (TAT) in patients with idiopathic pulmonary fibrosis (IPF).
Material and methods: Study grup consisted of 11 patients aged 51.5 ± 8.62 years with idiopathic pulmonary fibrosis and 20 healthy adults as control. Concentration of PC, PS TM, sSelE and TAT in plasma with ELISA method was assessed.
Results: We observed significantly lower plasma concentration of PC (98.24 ± 16.17% vs. 130.59 ± 19.03%), PS (71.31 ± ± 12.95% vs. 93.47 ± 18.63%), TM (2.67 ± 0.40 ng/ml vs. 3.99 ± 1.16 ng/ml) and significantly higher level of TAT complex (Me = 4.00 mg/ml vs. 2.20 mg/ml) and sSelE (Me = 36.40 ng/ml vs. 22.84 ng/ml) in patients with idiopathic pulmonary fibrosis as compared to controls.
Conclusion: In presented pilot study we observed decreased activity of protein C system and increased thrombin generation in peripheral blood of patients with idiopathic pulmonary fibrosis.

Abstract

Introduction: The natural anticoagulant - activated protein C system plays an important role in the pathogenesis of idiopathic pulmonary fibrosis. The purpose of this study was to evaluate the concentration of protein C (PC), protein S (PS), thrombomodulin (TM), selectin E (sSelE), and thrombin–antithrombin complex (TAT) in patients with idiopathic pulmonary fibrosis (IPF).
Material and methods: Study grup consisted of 11 patients aged 51.5 ± 8.62 years with idiopathic pulmonary fibrosis and 20 healthy adults as control. Concentration of PC, PS TM, sSelE and TAT in plasma with ELISA method was assessed.
Results: We observed significantly lower plasma concentration of PC (98.24 ± 16.17% vs. 130.59 ± 19.03%), PS (71.31 ± ± 12.95% vs. 93.47 ± 18.63%), TM (2.67 ± 0.40 ng/ml vs. 3.99 ± 1.16 ng/ml) and significantly higher level of TAT complex (Me = 4.00 mg/ml vs. 2.20 mg/ml) and sSelE (Me = 36.40 ng/ml vs. 22.84 ng/ml) in patients with idiopathic pulmonary fibrosis as compared to controls.
Conclusion: In presented pilot study we observed decreased activity of protein C system and increased thrombin generation in peripheral blood of patients with idiopathic pulmonary fibrosis.
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Keywords

idiopathic pulmonary fibrosis; activated protein C; complex TAT

About this article
Title

Protein C system in patients with idiopathic pulmonary fibrosis - preliminary report

Journal

Advances in Respiratory Medicine

Issue

Vol 76, No 4 (2008)

Pages

225-228

Published online

2008-06-22

Bibliographic record

Pneumonol Alergol Pol 2008;76(4):225-228.

Keywords

idiopathic pulmonary fibrosis
activated protein C
complex TAT

Authors

Anna Kiziewicz
Ewa Żekanowska
Krzysztof Cieśliński
Krzysztof Góralczyk

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