open access

Vol 76, No 4 (2008)
CASE REPORTS
Published online: 2008-06-22
Submitted: 2013-02-22
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Pulmonary epithelioid haemangioendothelioma - interferon 2-alpha treatment - case report

Elżbieta Radzikowska, Ewa Szczepulska-Wójcik, Mariusz Chabowski, Karina Oniszh, Renata Langfort, Kazimierz Roszkowski
Pneumonol Alergol Pol 2008;76(4):281-285.

open access

Vol 76, No 4 (2008)
CASE REPORTS
Published online: 2008-06-22
Submitted: 2013-02-22

Abstract

A 62-year-old, obese woman, smoking 10 pack/year was admitted to the National Tuberculosis and Lung Diseases Research Institute to diagnose small, round opacities revealed by routine chest X-ray examination. These lesions had been observed for 5 years. The patient had been treated for psoriasis, hypertension, and insulin-independent diabetes. On admission she was in good condition, complaining of a slight productive cough as well as intermittent osteoarticular pain. Physical examination revealed cutaneous psoriatic lesions, slight edema of the lower limbs, and clubbed fingers. Tuberculin test was positive.
Chest Computer Tomography scanning showed partially calcified nodules (up to 1cm in diameter) located in the middle and base areas of both lungs. No evidence of hilar nor mediastinal lymph node enlargement was seen. Lung specimens displayed intraalveolar and intravascular growth of neoplastic cells. Immunohistochemical expression of Factor VIII, CD31 and CD34 antigens was present. Pulmonary epithelioid haemangioendothelioma was diagnosed.
After 6 months of observation, progression of the disease was shown. Interferon alpha treatment was introduced. During the therapy, a slight regression of pulmonary changes was noticed and since then stabilization of the disease was observed.

Abstract

A 62-year-old, obese woman, smoking 10 pack/year was admitted to the National Tuberculosis and Lung Diseases Research Institute to diagnose small, round opacities revealed by routine chest X-ray examination. These lesions had been observed for 5 years. The patient had been treated for psoriasis, hypertension, and insulin-independent diabetes. On admission she was in good condition, complaining of a slight productive cough as well as intermittent osteoarticular pain. Physical examination revealed cutaneous psoriatic lesions, slight edema of the lower limbs, and clubbed fingers. Tuberculin test was positive.
Chest Computer Tomography scanning showed partially calcified nodules (up to 1cm in diameter) located in the middle and base areas of both lungs. No evidence of hilar nor mediastinal lymph node enlargement was seen. Lung specimens displayed intraalveolar and intravascular growth of neoplastic cells. Immunohistochemical expression of Factor VIII, CD31 and CD34 antigens was present. Pulmonary epithelioid haemangioendothelioma was diagnosed.
After 6 months of observation, progression of the disease was shown. Interferon alpha treatment was introduced. During the therapy, a slight regression of pulmonary changes was noticed and since then stabilization of the disease was observed.
Citation Formats

Keywords

pulmonary epithelioid haemangioendothelioma; lung; interferon 2-alpha

About this article
Title

Pulmonary epithelioid haemangioendothelioma - interferon 2-alpha treatment - case report

Journal

Advances in Respiratory Medicine

Issue

Vol 76, No 4 (2008)

Pages

281-285

Published online

2008-06-22

Bibliographic record

Pneumonol Alergol Pol 2008;76(4):281-285.

Keywords

pulmonary epithelioid haemangioendothelioma
lung
interferon 2-alpha

Authors

Elżbieta Radzikowska
Ewa Szczepulska-Wójcik
Mariusz Chabowski
Karina Oniszh
Renata Langfort
Kazimierz Roszkowski

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