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open access

Vol 76, No 5 (2008)
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Published online: 2008-09-17
Submitted: 2013-02-22
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The incidence and pathogenesis of cancer anorexia-cachexia syndrome in lung cancer

Monika Kosacka, Bożena Weryńska, Marcin Gołecki, Renata Jankowska, Ewa Passowicz-Muszyńska
Pneumonol Alergol Pol 2008;76(5):360-365.

open access

Vol 76, No 5 (2008)
REVIEWS
Published online: 2008-09-17
Submitted: 2013-02-22

Abstract

The cachexia-anorexia syndrome (CACS) is common and important implication of cancer. It occurs in 30% to 80% cancer patients. At the time of diagnosis of lung cancer CACS is not yet very important problem, but the weight loss increases with progression of the cancer. CACS is characterized by anorexia, weight loss, weakness, impaired immune system and metabolic dysfunction. Weight loss is a potent stimulus to food intake in normal humans. The persistence of anorexia in cancer patients, therefore, implies a failure of this adaptive feeding response. The weight loss in patients with CACS differs from that in simple starvation or anorexia nervosa.
Most research effort has focused on the role of cytokines as mediators of CACS. The role of TNF-α, IL-1 and IL-6 in CACS development has been evaluated and confirmed in many research, but some investigators suggest that the changes in cytokines’ levels could be the result rather than the cause of CACS. A few of the latest studies concentrate on the role of nuclear factor kappa B and prevention of CACS by its inhibitors.
CACS is an independent predictor of shorter survival and increases the risk of treatment failure and toxicity.

Abstract

The cachexia-anorexia syndrome (CACS) is common and important implication of cancer. It occurs in 30% to 80% cancer patients. At the time of diagnosis of lung cancer CACS is not yet very important problem, but the weight loss increases with progression of the cancer. CACS is characterized by anorexia, weight loss, weakness, impaired immune system and metabolic dysfunction. Weight loss is a potent stimulus to food intake in normal humans. The persistence of anorexia in cancer patients, therefore, implies a failure of this adaptive feeding response. The weight loss in patients with CACS differs from that in simple starvation or anorexia nervosa.
Most research effort has focused on the role of cytokines as mediators of CACS. The role of TNF-α, IL-1 and IL-6 in CACS development has been evaluated and confirmed in many research, but some investigators suggest that the changes in cytokines’ levels could be the result rather than the cause of CACS. A few of the latest studies concentrate on the role of nuclear factor kappa B and prevention of CACS by its inhibitors.
CACS is an independent predictor of shorter survival and increases the risk of treatment failure and toxicity.

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Keywords

cancer anorexia-cachexia syndrome; lung cancer

About this article
Title

The incidence and pathogenesis of cancer anorexia-cachexia syndrome in lung cancer

Journal

Advances in Respiratory Medicine

Issue

Vol 76, No 5 (2008)

Pages

360-365

Published online

2008-09-17

Bibliographic record

Pneumonol Alergol Pol 2008;76(5):360-365.

Keywords

cancer anorexia-cachexia syndrome
lung cancer

Authors

Monika Kosacka
Bożena Weryńska
Marcin Gołecki
Renata Jankowska
Ewa Passowicz-Muszyńska

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