open access
The incidence and pathogenesis of cancer anorexia-cachexia syndrome in lung cancer
open access
Abstract
Most research effort has focused on the role of cytokines as mediators of CACS. The role of TNF-α, IL-1 and IL-6 in CACS development has been evaluated and confirmed in many research, but some investigators suggest that the changes in cytokines’ levels could be the result rather than the cause of CACS. A few of the latest studies concentrate on the role of nuclear factor kappa B and prevention of CACS by its inhibitors.
CACS is an independent predictor of shorter survival and increases the risk of treatment failure and toxicity.
Abstract
Most research effort has focused on the role of cytokines as mediators of CACS. The role of TNF-α, IL-1 and IL-6 in CACS development has been evaluated and confirmed in many research, but some investigators suggest that the changes in cytokines’ levels could be the result rather than the cause of CACS. A few of the latest studies concentrate on the role of nuclear factor kappa B and prevention of CACS by its inhibitors.
CACS is an independent predictor of shorter survival and increases the risk of treatment failure and toxicity.
Keywords
cancer anorexia-cachexia syndrome; lung cancer


Title
The incidence and pathogenesis of cancer anorexia-cachexia syndrome in lung cancer
Journal
Advances in Respiratory Medicine
Issue
Article type
Review paper
Pages
360-365
Published online
2008-09-17
Bibliographic record
Pneumonol Alergol Pol 2008;76(5):360-365.
Keywords
cancer anorexia-cachexia syndrome
lung cancer
Authors
Monika Kosacka
Bożena Weryńska
Marcin Gołecki
Renata Jankowska
Ewa Passowicz-Muszyńska