open access

Vol 76, No 6 (2008)
REVIEWS
Published online: 2008-10-31
Submitted: 2013-02-22
Get Citation

Bronchopulmonary dysplasia - early and long-term pulmonary sequelae

Edyta Głowacka, Grzegorz Lis
Pneumonol Alergol Pol 2008;76(6):437-445.

open access

Vol 76, No 6 (2008)
REVIEWS
Published online: 2008-10-31
Submitted: 2013-02-22

Abstract

Improvement in perinatal care have resulted in significantly increased survival of premature infants. Discontinuation of correct intrauterine lung development and a necessity of oxygen-therapy and/or mechanical ventilation become a reason of bronchopulmonary dysplasia (BPD). In the first period of life the main complaint of these patients is oxygen dependence. Moreover the risk of serious infections of lower respiratory tract (particularly RSV) increases. This becomes the reason of readmission of about 50% prematures with diagnosed BPD in the first year of life. The main problem of these patients is airway obstruction, which very often doesn’t respond to brochodilatators. The probable reason of these disturbances is imperfect development of respiratory system and remodelling of respiratory tract. Reduction in lung function (reduced FEV1, PEF, FVC) persists until adolescence. Acceleration of the decrease in FEV1/FVC ratio may suggest that these patients are a risk group of COPD development. The assessment of lung radiography at the age of 11 years of former prematures with diagnosed BPD reveals the presence of persistent emphysematic changes (86% of these children had one or more bubbles). Abnormalities in chest high resolution CT occur in the majority of these patients (in 81.3% of the 10-years-olds group and in 92.5% of 18-year-olds group). Further prospective long-term study of prematures is essential for the establishment of remote prognosis and treatment standards.

Abstract

Improvement in perinatal care have resulted in significantly increased survival of premature infants. Discontinuation of correct intrauterine lung development and a necessity of oxygen-therapy and/or mechanical ventilation become a reason of bronchopulmonary dysplasia (BPD). In the first period of life the main complaint of these patients is oxygen dependence. Moreover the risk of serious infections of lower respiratory tract (particularly RSV) increases. This becomes the reason of readmission of about 50% prematures with diagnosed BPD in the first year of life. The main problem of these patients is airway obstruction, which very often doesn’t respond to brochodilatators. The probable reason of these disturbances is imperfect development of respiratory system and remodelling of respiratory tract. Reduction in lung function (reduced FEV1, PEF, FVC) persists until adolescence. Acceleration of the decrease in FEV1/FVC ratio may suggest that these patients are a risk group of COPD development. The assessment of lung radiography at the age of 11 years of former prematures with diagnosed BPD reveals the presence of persistent emphysematic changes (86% of these children had one or more bubbles). Abnormalities in chest high resolution CT occur in the majority of these patients (in 81.3% of the 10-years-olds group and in 92.5% of 18-year-olds group). Further prospective long-term study of prematures is essential for the establishment of remote prognosis and treatment standards.
Get Citation

Keywords

bronchopulmonary dysplasia; pulmonary sequelae

About this article
Title

Bronchopulmonary dysplasia - early and long-term pulmonary sequelae

Journal

Advances in Respiratory Medicine

Issue

Vol 76, No 6 (2008)

Pages

437-445

Published online

2008-10-31

Bibliographic record

Pneumonol Alergol Pol 2008;76(6):437-445.

Keywords

bronchopulmonary dysplasia
pulmonary sequelae

Authors

Edyta Głowacka
Grzegorz Lis

Important: This website uses cookies.tanya dokter More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Czasopismo Pneumonologia i Alergologia Polska dostęne jest również w Ikamed - księgarnia medyczna

Wydawcą serwisu jest "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl