open access

Vol 76, No 6 (2008)
REVIEWS
Published online: 2008-10-31
Submitted: 2013-02-22
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The role of interleukin-18 in the pathogenesis of bronchial asthma and other allergic diseases and in activation of basophils and mastocytes

Marek Kamiński, Karolina Kłoda, Andrzej Pawlik
Pneumonol Alergol Pol 2008;76(6):432-436.

open access

Vol 76, No 6 (2008)
REVIEWS
Published online: 2008-10-31
Submitted: 2013-02-22

Abstract

Interleukin-18 is a proinflammatory cytokine produced by a wide range of cells and is involved in the pathogenesis of several inflammatory diseases such as atopic asthma. It was recently demonstrated that IL-18 acts on T cells to induce airway inflammation and airway hyperresponsiveness. These observations strongly indicate that IL-18 stimulates Th1 cells to produce cytokines and chemokines responsible for the airway infiltration and inflammatory responsiveness. Moreover IL-18 activates mast cells and basophils playing the important role in atopy. Atopic asthma is characterized by eosinophilic airway inflammation, remodeling, mucus hypersecretion and high serum levels of IgE. Most current data suggest that asthma drives development of a Th2 lymphocyte-predominant immune response, which is associated with atopy and IgE mediated inflammation via pathways involving the production of proinflammatory cytokines such as IL-18. Here we discuss the functional role of IL-18 in activation of mast cells and basophils and pathogenesis of allergic diseases.

Abstract

Interleukin-18 is a proinflammatory cytokine produced by a wide range of cells and is involved in the pathogenesis of several inflammatory diseases such as atopic asthma. It was recently demonstrated that IL-18 acts on T cells to induce airway inflammation and airway hyperresponsiveness. These observations strongly indicate that IL-18 stimulates Th1 cells to produce cytokines and chemokines responsible for the airway infiltration and inflammatory responsiveness. Moreover IL-18 activates mast cells and basophils playing the important role in atopy. Atopic asthma is characterized by eosinophilic airway inflammation, remodeling, mucus hypersecretion and high serum levels of IgE. Most current data suggest that asthma drives development of a Th2 lymphocyte-predominant immune response, which is associated with atopy and IgE mediated inflammation via pathways involving the production of proinflammatory cytokines such as IL-18. Here we discuss the functional role of IL-18 in activation of mast cells and basophils and pathogenesis of allergic diseases.
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Keywords

cytokines; interleukin-18; bronchial asthma; allergic response

About this article
Title

The role of interleukin-18 in the pathogenesis of bronchial asthma and other allergic diseases and in activation of basophils and mastocytes

Journal

Advances in Respiratory Medicine

Issue

Vol 76, No 6 (2008)

Pages

432-436

Published online

2008-10-31

Bibliographic record

Pneumonol Alergol Pol 2008;76(6):432-436.

Keywords

cytokines
interleukin-18
bronchial asthma
allergic response

Authors

Marek Kamiński
Karolina Kłoda
Andrzej Pawlik

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