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Vol 77, No 3 (2009)
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Published online: 2009-04-23
Submitted: 2013-02-22
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D-dimer in diagnosis and treatment of pulmonary embolism

Anna Fijałkowska
Pneumonol Alergol Pol 2009;77(3):271-275.

open access

Vol 77, No 3 (2009)
REVIEWS
Published online: 2009-04-23
Submitted: 2013-02-22

Abstract

D-dimer level estimation, specific fibrin degradation product, is a permanent part of diagnostic strategies of pulmonary embolism (PE). Approximetly 30% of a suspected non-high risk PE can be ruled out with high sensitive D-dimer test when pre-test clinical probability is non-high. Recent guidelines underline that only very sensitive DD assays can be used. The main limitation of DD tests is relatively low specificity especially in hospitalized population, in elder patients, with cancer and in pregnancy. New indication for DD test mentioned in current guidelines is estimation of risk of recurrence after withdrawal of anticoagulant. Negative DD test identify patients with low risk of recurrence.

Abstract

D-dimer level estimation, specific fibrin degradation product, is a permanent part of diagnostic strategies of pulmonary embolism (PE). Approximetly 30% of a suspected non-high risk PE can be ruled out with high sensitive D-dimer test when pre-test clinical probability is non-high. Recent guidelines underline that only very sensitive DD assays can be used. The main limitation of DD tests is relatively low specificity especially in hospitalized population, in elder patients, with cancer and in pregnancy. New indication for DD test mentioned in current guidelines is estimation of risk of recurrence after withdrawal of anticoagulant. Negative DD test identify patients with low risk of recurrence.

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Keywords

D-dimer; pulmonary embolism; quidelines

About this article
Title

D-dimer in diagnosis and treatment of pulmonary embolism

Journal

Advances in Respiratory Medicine

Issue

Vol 77, No 3 (2009)

Pages

271-275

Published online

2009-04-23

Bibliographic record

Pneumonol Alergol Pol 2009;77(3):271-275.

Keywords

D-dimer
pulmonary embolism
quidelines

Authors

Anna Fijałkowska

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