open access

Vol 77, No 3 (2009)
REVIEWS
Published online: 2009-04-23
Submitted: 2013-02-22
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Methods of estimating concentration of the D-dimers used in venous thromboembolism diagnosis

Bartłomiej Walczak, Urszula Demkow, Anna Fijałkowska
Pneumonol Alergol Pol 2009;77(3):264-270.

open access

Vol 77, No 3 (2009)
REVIEWS
Published online: 2009-04-23
Submitted: 2013-02-22

Abstract

D-dimers (DD) are final products of stabilized fibrin degradation process. Elevated level of DD indicates parallel activation of both coagulation and fibrinolysis. D-dimers play important role in the diagnosis of deep vein thrombosis and pulmonary embolism. All diagnostic methods detecting DD are based on monoclonal antibodies. There are three basic techniques used to measure DD: latex agglutination, full blood agglutination and immunoenzymatic methods. Nowadays new methods based on in vivo detection of DD using antibodies labeled with technetium are under clinical evaluation.

Abstract

D-dimers (DD) are final products of stabilized fibrin degradation process. Elevated level of DD indicates parallel activation of both coagulation and fibrinolysis. D-dimers play important role in the diagnosis of deep vein thrombosis and pulmonary embolism. All diagnostic methods detecting DD are based on monoclonal antibodies. There are three basic techniques used to measure DD: latex agglutination, full blood agglutination and immunoenzymatic methods. Nowadays new methods based on in vivo detection of DD using antibodies labeled with technetium are under clinical evaluation.
Citation Formats

Keywords

D-dimers; laboratory diagnosis; pulmonary embolism; deep vein thrombosis

About this article
Title

Methods of estimating concentration of the D-dimers used in venous thromboembolism diagnosis

Journal

Advances in Respiratory Medicine

Issue

Vol 77, No 3 (2009)

Pages

264-270

Published online

2009-04-23

Bibliographic record

Pneumonol Alergol Pol 2009;77(3):264-270.

Keywords

D-dimers
laboratory diagnosis
pulmonary embolism
deep vein thrombosis

Authors

Bartłomiej Walczak
Urszula Demkow
Anna Fijałkowska

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