open access
Vol 77, No 4 (2009)
REVIEWS
Published online: 2009-06-26
Submitted: 2013-02-22
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Nongenomic effects of glucocorticoids
Alicja Grzanka, Jerzy Jarząb
Pneumonol Alergol Pol 2009;77(4):387-393.
open access
Vol 77, No 4 (2009)
REVIEWS
Published online: 2009-06-26
Submitted: 2013-02-22
Abstract
The review describes current advances in the knowledge on the mechanisms of glucocorticoid (GC) action. According to the
classic genomic model, GCs bind to intracellular receptors and subsequently regulate (directly or indirectly) gene transcription
and synthesis of proteins responsible for inflammatory processes. The nongenomic effects of GCs, occur rapidly within
seconds or minutes of drug administration, are mediated via a cytosolic but first of all by membrane GC receptors and lead to
activation of multiple signal transduction pathways of protein kinases (MAPK, Src, PI3K), cation channels or G protein-
-coupled receptors. Nongenomic effects may also occur without receptor involvement. The elucidation of nongenomic
actions provides new insights for the understanding of their anti-inflammatory and immunosuppressive GC effects.
Abstract
The review describes current advances in the knowledge on the mechanisms of glucocorticoid (GC) action. According to the
classic genomic model, GCs bind to intracellular receptors and subsequently regulate (directly or indirectly) gene transcription
and synthesis of proteins responsible for inflammatory processes. The nongenomic effects of GCs, occur rapidly within
seconds or minutes of drug administration, are mediated via a cytosolic but first of all by membrane GC receptors and lead to
activation of multiple signal transduction pathways of protein kinases (MAPK, Src, PI3K), cation channels or G protein-
-coupled receptors. Nongenomic effects may also occur without receptor involvement. The elucidation of nongenomic
actions provides new insights for the understanding of their anti-inflammatory and immunosuppressive GC effects.
Get Citation
Keywords
glucocorticoids; nongenomic and genomic action
About this articleTitle
Nongenomic effects of glucocorticoids
Journal
Advances in Respiratory Medicine
Issue
Pages
387-393
Published online
2009-06-26
Bibliographic record
Pneumonol Alergol Pol 2009;77(4):387-393.
Keywords
glucocorticoids
nongenomic and genomic action
Authors
Alicja Grzanka
Jerzy Jarząb
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