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Vol 77, No 4 (2009)
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Published online: 2009-06-26
Submitted: 2013-02-22
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Nongenomic effects of glucocorticoids

Alicja Grzanka, Jerzy Jarząb
Pneumonol Alergol Pol 2009;77(4):387-393.

open access

Vol 77, No 4 (2009)
REVIEWS
Published online: 2009-06-26
Submitted: 2013-02-22

Abstract

The review describes current advances in the knowledge on the mechanisms of glucocorticoid (GC) action. According to the classic genomic model, GCs bind to intracellular receptors and subsequently regulate (directly or indirectly) gene transcription and synthesis of proteins responsible for inflammatory processes. The nongenomic effects of GCs, occur rapidly within seconds or minutes of drug administration, are mediated via a cytosolic but first of all by membrane GC receptors and lead to activation of multiple signal transduction pathways of protein kinases (MAPK, Src, PI3K), cation channels or G protein- -coupled receptors. Nongenomic effects may also occur without receptor involvement. The elucidation of nongenomic actions provides new insights for the understanding of their anti-inflammatory and immunosuppressive GC effects.

Abstract

The review describes current advances in the knowledge on the mechanisms of glucocorticoid (GC) action. According to the classic genomic model, GCs bind to intracellular receptors and subsequently regulate (directly or indirectly) gene transcription and synthesis of proteins responsible for inflammatory processes. The nongenomic effects of GCs, occur rapidly within seconds or minutes of drug administration, are mediated via a cytosolic but first of all by membrane GC receptors and lead to activation of multiple signal transduction pathways of protein kinases (MAPK, Src, PI3K), cation channels or G protein- -coupled receptors. Nongenomic effects may also occur without receptor involvement. The elucidation of nongenomic actions provides new insights for the understanding of their anti-inflammatory and immunosuppressive GC effects.

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Keywords

glucocorticoids; nongenomic and genomic action

About this article
Title

Nongenomic effects of glucocorticoids

Journal

Advances in Respiratory Medicine

Issue

Vol 77, No 4 (2009)

Pages

387-393

Published online

2009-06-26

Bibliographic record

Pneumonol Alergol Pol 2009;77(4):387-393.

Keywords

glucocorticoids
nongenomic and genomic action

Authors

Alicja Grzanka
Jerzy Jarząb

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