open access
Nongenomic effects of glucocorticoids, an important mechanism of inhaled glucocorticoids action in asthma
open access
Abstract
Abstract
Keywords
inhaled glucocorticoids; nongenomic action; asthma


Title
Nongenomic effects of glucocorticoids, an important mechanism of inhaled glucocorticoids action in asthma
Journal
Advances in Respiratory Medicine
Issue
Article type
Review paper
Pages
453-459
Published online
2009-08-12
Bibliographic record
Pneumonol Alergol Pol 2009;77(5):453-459.
Keywords
inhaled glucocorticoids
nongenomic action
asthma
Authors
Alicja Grzanka
Jerzy Jarząb


- Grzanka A, Jarząb J. Niegenomowy mechanizm działania glikokortykosteroidów. Pneumonol Alergol Pol. 2009; 77: 387–393.
- Wanner A, Horvath G, Brieva JL, et al. Nongenomic actions of glucocorticosteroids on the airway vasculature in asthma. Proc Am Thorac Soc. 2004; 1(3): 235–238.
- Mendes ES, Pereira A, Danta I, et al. Comparative bronchial vasoconstrictive efficacy of inhaled glucocorticosteroids. Eur Respir J. 2003; 21(6): 989–993.
- Paredi P, Kharitonov SA, Barnes PJ. Correlation of exhaled breath temperature with bronchial blood flow in asthma. Respir Res. 2005: 6–15.
- Sun HW, Miao CY, Liu L, et al. Rapid inhibitory effect of glucocorticoids on airway smooth muscle contractions in guinea pigs. Steroids. 2006; 71(2): 154–159.
- Rodrigo GJ. Rapid effects of inhaled corticosteroids in acute asthma: an evidence-based evaluation. Chest. 2006; 130(5): 1301–1311.
- Singhi S, Banerjee S, Nanjundaswamy H. Inhaled budesonide in acute asthma. J Paediatr Child Health. 1999; 35(5): 483–487.
- Rodrigo GJ. Comparison of inhaled fluticasone with intravenous hydrocortisone in the treatment of adult acute asthma. Am J Respir Crit Care Med. 2005; 171(11): 1231–1236.
- Horvath G, Vasas S, Wanner A. Inhaled corticosteroids reduce asthma-associated airway hyperperfusion through genomic and nongenomic mechanisms. Pulm Pharmacol Ther. 2007; 20(2): 157–162.
- Górski P. Przypadek z Kliniki Pneumonologii i Alergologii UM w Łodzi. Alergia. 2008; 1: 23–27.
- Guttman A, Afilalo M, Colacone A, et al. The effects of combined intravenous and inhaled steroids (beclomethasone dipropionate) for the emergency treatment of acute asthma. The Asthma ED Study Group. Acad Emerg Med. 1997; 4(2): 100–106.
- Afilalo M, Guttman A, Colacone A, et al. Efficacy of inhaled steroids (beclomethasone dipropionate) for treatment of mild to moderately severe asthma in the emergency department: a randomized clinical trial. Ann Emerg Med. 1999; 33(3): 304–309.
- Reddel HK, Barnes DJ. Exacerbation Advisory Panel. Pharmacological strategies for self-management of asthma exacerbations. Eur Respir J. 2006; 28(1): 182–199.
- National Institutes of Health. National Heart, Lung and Blood Institute: Global initiative for asthma. Global strategy for asthma management and prevention. www.ginasthma.com.
- Frezza G, Terra-Filho J, Martinez JAB, et al. Rapid effect of inhaled steroids on nocturnal worsening of asthma. Thorax. 2003; 58(7): 632–633.
- Edmonds M, Camargo C, Brenner B, et al. Replacement of Oral Corticosteroids With Inhaled Corticosteroids in the Treatment of Acute Asthma Following Emergency Department Discharge. Chest. 2002; 121(6): 1798–1805.
- FitzGerald JM, Shragge D, Haddon J, et al. A randomized, controlled trial of high dose, inhaled budesonide versus oral prednisone in patients discharged from the emergency department following an acute asthma exacerbation. Can Respir J. 2000; 7(1): 61–67.
- Di Franco A, Bacci E, Bartoli ML, et al. Inhaled fluticasone propionate is effective as well as oral prednisone in reducing sputum eosinophilia during exacerbations of asthma which do not require hospitalization. Pulm Pharmacol Ther. 2006; 19(5): 353–360.
- Croxtall JD, Choudhury Q, Flower RJ. Glucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor-dependent, transcription-independent mechanism. Br J Pharmacol. 2000; 130(2): 289–298.
- Dworski R, Fitzgerald GA, Oates JA, et al. Effect of oral prednisone on airway inflammatory mediators in atopic asthma. Am J Respir Crit Care Med. 1994; 149(4 Pt 1): 953–959.
- Sano A, Muñoz NM, Sano H, et al. Inhibition of cPLA2 translocation and leukotriene C4 secretion by fluticasone propionate in exogenously activated human eosinophils. Am J Respir Crit Care Med. 1999; 159(6): 1903–1909.
- Roviezzo F, Getting SJ, Paul-Clark MJ, et al. The annexin-1 knockout mouse: what it tells us about the inflammatory response. J Physiol Pharmacol. 2002; 53(4 Pt 1): 541–553.
- Zaitsu M, Hamasaki Y, Tsuji K, et al. Dexamethasone accelerates catabolism of leukotriene C4 in bronchial epithelial cells. Eur Respir J. 2003; 22(1): 35–42.
- Malcher-Lopes R, Franco A, Tasker JG. Glucocorticoids shift arachidonic acid metabolism toward endocannabinoid synthesis: a non-genomic anti-inflammatory switch. Eur J Pharmacol. 2008; 583(2-3): 322–339.
- McDanel DL, Muller BA. The linkage between Churg-Strauss syndrome and leukotriene receptor antagonists: fact or fiction? Ther Clin Risk Manag. 2005; 1(2): 125–140.
- Li X, Wilson JW. Increased vascularity of the bronchial mucosa in mild asthma. Am J Respir Crit Care Med. 1997; 156(1): 229–233.
- Orsida BE, Ward C, Li X, et al. Effect of a long-acting beta2-agonist over three months on airway wall vascular remodeling in asthma. Am J Respir Crit Care Med. 2001; 164(1): 117–121.
- Chetta A, Zanini A, Foresi A, et al. Vascular component of airway remodeling in asthma is reduced by high dose of fluticasone. Am J Respir Crit Care Med. 2003; 167(5): 751–757.
- Orsida BE, Li X, Hickey B, et al. Vascularity in asthmatic airways: relation to inhaled steroid dose. Thorax. 1999; 54(4): 289–295.
- Trigg CJ, Manolitsas ND, Wang J, et al. Placebo-controlled immunopathologic study of four months of inhaled corticosteroids in asthma. Am J Respir Crit Care Med. 1994; 150(1): 17–22.