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Vol 77, No 6 (2009)
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Published online: 2009-11-30
Submitted: 2013-02-22
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Vascular endothelial growth factor - structure, function and role in airways inflammation and the clinical course of asthma

Krzysztof Gomułka, Jerzy Liebhart
Pneumonol Alergol Pol 2009;77(6):549-553.

open access

Vol 77, No 6 (2009)
REVIEWS
Published online: 2009-11-30
Submitted: 2013-02-22

Abstract

Vascular endothelial growth factor (VEGF) is produced by a wide range of cells and plays an important role in normal and pathological angiogenesis. The formation of the vascular system is essential for inflammatory process in airways, especially in the course of chronic lung diseases - for example bronchial asthma. Increased level of VEGF in serum and induced sputum has been demonstrated in patients with stable asthma, as well as during the exacerbation of this disease. VEGF end VEGF-receptor’s expressions is closely correlated with neovascularization and seems to be an important predictor of the lung’s remodeling. Due to direct causative relationship between inflammatory process and angiogenesis in airways, it was suggested, that inhibiting VEGF’s activity would have an anti-inflammatory effect on airways. In this article the potential role of vascular endothelial growth factor in airways inflammation, remodeling and the clinical course of bronchial asthma is presented.

Abstract

Vascular endothelial growth factor (VEGF) is produced by a wide range of cells and plays an important role in normal and pathological angiogenesis. The formation of the vascular system is essential for inflammatory process in airways, especially in the course of chronic lung diseases - for example bronchial asthma. Increased level of VEGF in serum and induced sputum has been demonstrated in patients with stable asthma, as well as during the exacerbation of this disease. VEGF end VEGF-receptor’s expressions is closely correlated with neovascularization and seems to be an important predictor of the lung’s remodeling. Due to direct causative relationship between inflammatory process and angiogenesis in airways, it was suggested, that inhibiting VEGF’s activity would have an anti-inflammatory effect on airways. In this article the potential role of vascular endothelial growth factor in airways inflammation, remodeling and the clinical course of bronchial asthma is presented.
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Keywords

vascular endothelial growth factor; bronchial asthma; angiogenesis; remodeling

About this article
Title

Vascular endothelial growth factor - structure, function and role in airways inflammation and the clinical course of asthma

Journal

Advances in Respiratory Medicine

Issue

Vol 77, No 6 (2009)

Pages

549-553

Published online

2009-11-30

Bibliographic record

Pneumonol Alergol Pol 2009;77(6):549-553.

Keywords

vascular endothelial growth factor
bronchial asthma
angiogenesis
remodeling

Authors

Krzysztof Gomułka
Jerzy Liebhart

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