open access

Vol 77, No 6 (2009)
REVIEWS
Published online: 2009-11-30
Submitted: 2013-02-22
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Disorders with elevated immunoglobulin E levels

Urszula Nowicka
Pneumonol Alergol Pol 2009;77(6):533-540.

open access

Vol 77, No 6 (2009)
REVIEWS
Published online: 2009-11-30
Submitted: 2013-02-22

Abstract

Immunoglobulin E (IgE) was first described in 1967. It has the lowest serum concentration of all circulating immunoglobulin isotypes. Serum IgE concentration at birth is low and rises until the age of 10-15 years. The increment of serum IgE in children with predisposition to atopic reactions is usually more abrupt. Total serum IgE levels decline from the second to the eight decade of life. Usually, elevated IgE concentration is related to atopic diseases but there are many other disorders combined with elevated serum IgE (for example: infections, neoplasms, immunodeficiency syndromes, skin disorders, inflammatory diseases). The spectrum of diseases combined with serum IgE elevation was presented in the present article.

Abstract

Immunoglobulin E (IgE) was first described in 1967. It has the lowest serum concentration of all circulating immunoglobulin isotypes. Serum IgE concentration at birth is low and rises until the age of 10-15 years. The increment of serum IgE in children with predisposition to atopic reactions is usually more abrupt. Total serum IgE levels decline from the second to the eight decade of life. Usually, elevated IgE concentration is related to atopic diseases but there are many other disorders combined with elevated serum IgE (for example: infections, neoplasms, immunodeficiency syndromes, skin disorders, inflammatory diseases). The spectrum of diseases combined with serum IgE elevation was presented in the present article.
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Keywords

IgE; allergic diseases; malignant diseases; immunodeficiency syndromes; parasitic infections

About this article
Title

Disorders with elevated immunoglobulin E levels

Journal

Advances in Respiratory Medicine

Issue

Vol 77, No 6 (2009)

Pages

533-540

Published online

2009-11-30

Bibliographic record

Pneumonol Alergol Pol 2009;77(6):533-540.

Keywords

IgE
allergic diseases
malignant diseases
immunodeficiency syndromes
parasitic infections

Authors

Urszula Nowicka

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