open access

Vol 77, No 6 (2009)
ORIGINAL PAPERS
Published online: 2009-11-30
Submitted: 2013-02-22
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Leptin serum levels in cachectic and non-cachectic lung cancer patients

Bożena Weryńska, Monika Kosacka, Marcin Gołecki, Renata Jankowska
Pneumonol Alergol Pol 2009;77(6):500-506.

open access

Vol 77, No 6 (2009)
ORIGINAL PAPERS
Published online: 2009-11-30
Submitted: 2013-02-22

Abstract


Introduction: Leptin, protein taking part in body mass regulation, might play a role in cancer cachexia development. The aim of the study was to measure leptin serum levels in cachectic, non-cachectic lung cancer patients, healthy controls and to correlate leptin concentration with nutritional status markers.
Material and methods: 40 lung cancer patients were enrolled into the study: 20 with cachexia, 20 without cachexia, and 10 healthy controls. Leptin serum concentration, body mass, BMI, arm circumference and skin triceps fold thickness were measured in each subject.
Results: Serum leptin level in cachectic cancer patients was significantly lower than in non-cachectic and healthy controls. Leptin concentration correlated with body mass, arm circumference and skin triceps fold thickness.
Conclusions: Cachectic lung cancer patients have significantly lower serum leptin concentrations than non-cachectic patients and healthy controls which may suggest, that leptin does not play an important role in cancer cachexia development. Leptin levels positively correlate with good nutritional status markers. Non-cachectic lung cancer patients have similar leptin serum levels as healthy controls.

Abstract


Introduction: Leptin, protein taking part in body mass regulation, might play a role in cancer cachexia development. The aim of the study was to measure leptin serum levels in cachectic, non-cachectic lung cancer patients, healthy controls and to correlate leptin concentration with nutritional status markers.
Material and methods: 40 lung cancer patients were enrolled into the study: 20 with cachexia, 20 without cachexia, and 10 healthy controls. Leptin serum concentration, body mass, BMI, arm circumference and skin triceps fold thickness were measured in each subject.
Results: Serum leptin level in cachectic cancer patients was significantly lower than in non-cachectic and healthy controls. Leptin concentration correlated with body mass, arm circumference and skin triceps fold thickness.
Conclusions: Cachectic lung cancer patients have significantly lower serum leptin concentrations than non-cachectic patients and healthy controls which may suggest, that leptin does not play an important role in cancer cachexia development. Leptin levels positively correlate with good nutritional status markers. Non-cachectic lung cancer patients have similar leptin serum levels as healthy controls.
Get Citation

Keywords

lung cancer; cancer cachexia; leptin

About this article
Title

Leptin serum levels in cachectic and non-cachectic lung cancer patients

Journal

Advances in Respiratory Medicine

Issue

Vol 77, No 6 (2009)

Pages

500-506

Published online

2009-11-30

Bibliographic record

Pneumonol Alergol Pol 2009;77(6):500-506.

Keywords

lung cancer
cancer cachexia
leptin

Authors

Bożena Weryńska
Monika Kosacka
Marcin Gołecki
Renata Jankowska

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