open access

Vol 78, No 4 (2010)
CASE REPORTS
Published online: 2010-07-08
Submitted: 2013-02-22
Get Citation

Simultaneous detection of tumor cells and the positive result of genetic test for Mycobacterium tuberculosis in pleural effusion

Monika Czystowska, Anna Stokłosa, Ewa Szczepulska-Wójcik, Krystyna Maszkowska-Kopij, Lucyna Opoka, Agnieszka Skoczylas, Dorota Górecka
Pneumonol Alergol Pol 2010;78(4):296-301.

open access

Vol 78, No 4 (2010)
CASE REPORTS
Published online: 2010-07-08
Submitted: 2013-02-22

Abstract

Pleural effusion is a frequently observed lesion in the course of respiratory diseases such as inflammatory process and cancer metastasis. Its cause may be either tuberculosis (the most common extrapulmonary location is the pleura) and malignant disease of the pleura. Confirmation of tuberculosis is often troublesome. The primary site of cancer may be also difficult to find despite the application of difficult diagnostic methods. Below we present history of 79-year-old female in whom carcinomatous cells and positive result of PCR for Mycobacterium tuberculosis in pleural fluid were discovered simultaneously suggesting the tuberculosis and cancer of unknown primary origin.
Pneumonol. Alergol. Pol. 2010; 78, 4: 296-301

Abstract

Pleural effusion is a frequently observed lesion in the course of respiratory diseases such as inflammatory process and cancer metastasis. Its cause may be either tuberculosis (the most common extrapulmonary location is the pleura) and malignant disease of the pleura. Confirmation of tuberculosis is often troublesome. The primary site of cancer may be also difficult to find despite the application of difficult diagnostic methods. Below we present history of 79-year-old female in whom carcinomatous cells and positive result of PCR for Mycobacterium tuberculosis in pleural fluid were discovered simultaneously suggesting the tuberculosis and cancer of unknown primary origin.
Pneumonol. Alergol. Pol. 2010; 78, 4: 296-301
Get Citation

Keywords

pleural tuberculosis; cancer of unknown primary site; immunohistochemical examination

About this article
Title

Simultaneous detection of tumor cells and the positive result of genetic test for Mycobacterium tuberculosis in pleural effusion

Journal

Advances in Respiratory Medicine

Issue

Vol 78, No 4 (2010)

Pages

296-301

Published online

2010-07-08

Bibliographic record

Pneumonol Alergol Pol 2010;78(4):296-301.

Keywords

pleural tuberculosis
cancer of unknown primary site
immunohistochemical examination

Authors

Monika Czystowska
Anna Stokłosa
Ewa Szczepulska-Wójcik
Krystyna Maszkowska-Kopij
Lucyna Opoka
Agnieszka Skoczylas
Dorota Górecka

References (22)
  1. Grzelewska-Rzymowska I. Gruźlica i inne mykobakteriozy. In: Szczeklik A. ed. Choroby wewnętrzne. . Med. Prakt., Kraków 2005: 591–602.
  2. Korzeniewska-Koseła M. Gruźlica i choroby układu oddechowego w Polsce w 2008 roku. Instytut Gruźlicy i Chorób Płuc, Warszawa 2009.
  3. Schaaf HS, Zumla A. Tuberculosis. A comprehensive clinical reference. Saunders Elsevier Ltd, Oxford 2009.
  4. Remiszewski P, Słodkowska J, Wiatr E, et al. Fatal infection in patients treated for small cell lung cancer in the Institute of Tuberculosis and Chest Diseases in the years 1980-1994. Lung Cancer. 2001; 31(2-3): 101–110.
  5. de Wit D, Maartens G, Steyn L. A comparative study of the polymerase chain reaction and conventional procedures for the diagnosis of tuberculous pleural effusion. Tuber Lung Dis. 1992; 73(5): 262–267.
  6. Beige J, Lokies J, Schaberg T, et al. Clinical evaluation of a Mycobacterium tuberculosis PCR assay. J Clin Microbiol. 1995; 33(1): 90–95.
  7. Varadhachary GR. Carcinoma of unknown primary origin. Gastrointest Cancer Res. 2007; 1(6): 229–235.
  8. Briasoulis E, Pavlidis N, Felip E, et al. ESMO Guidelines Working Group. Cancers of unknown primary site: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann Oncol. 2009; 20 Suppl 4: 154–155.
  9. Bugat R, Bataillard A, Lesimple T, et al. FNCLCC. Summary of the Standards, Options and Recommendations for the management of patients with carcinoma of unknown primary site (2002). Br J Cancer. 2003; 89 Suppl 1: S59–S66.
  10. Krzemieniecki K. Ogólne zasady diagnostyki nowotworów. In: Szczeklik A. ed. Choroby wewnętrzne. . Med. Prakt., Kraków 2005: 1993–1996.
  11. McMillan JH, Levine E, Stephens RH. Computed tomography in the evaluation of metastatic adenocarcinoma from an unknown primary site. A retrospective study. Radiology. 1982; 143(1): 143–146.
  12. Abbruzzese JL, Abbruzzese MC, Lenzi R, et al. Analysis of a diagnostic strategy for patients with suspected tumors of unknown origin. J Clin Oncol. 1995; 13(8): 2094–2103.
  13. Rusthoven KE, Koshy M, Paulino AC. The role of fluorodeoxyglucose positron emission tomography in cervical lymph node metastases from an unknown primary tumor. Cancer. 2004; 101(11): 2641–2649.
  14. Varadhachary GR, Abbruzzese JL, Lenzi R. Diagnostic strategies for unknown primary cancer. Cancer. 2004; 100(9): 1776–1785.
  15. Olson JA, Morris EA, Van Zee KJ, et al. Magnetic resonance imaging facilitates breast conservation for occult breast cancer. Ann Surg Oncol. 2000; 7(6): 411–415.
  16. Sturgeon C. Practice guidelines for tumor marker use in the clinic. Clin Chem. 2002; 48(8): 1151–1159.
  17. Sheth SS. Elevated CA 125 in advanced abdominal or pelvic tuberculosis. Int J Gynaecol Obstet. 1996; 52(2): 167–171.
  18. Giovanella L, Ceriani L, Giardina G, et al. Serum cytokeratin fragment 21.1 (CYFRA 21.1) as tumour marker for breast cancer: comparison with carbohydrate antigen 15.3 (CA 15.3) and carcinoembryonic antigen (CEA). Clin Chem Lab Med. 2002; 40(3): 298–303.
  19. Bejarano PA, Baughman RP, Biddinger PW, et al. Surfactant proteins and thyroid transcription factor-1 in pulmonary and breast carcinomas. Mod Pathol. 1996; 9(4): 445–452.
  20. Tan D, Li Q, Deeb G, et al. Thyroid transcription factor-1 expression prevalence and its clinical implications in non-small cell lung cancer: a high-throughput tissue microarray and immunohistochemistry study. Hum Pathol. 2003; 34(6): 597–604.
  21. Chen H, Brahmer J. Management of malignant pleural effusion. Curr Oncol Rep. 2008; 10(4): 287–293.
  22. Neragi-Miandoab S. Malignant pleural effusion, current and evolving approaches for its diagnosis and management. Lung Cancer. 2006; 54(1): 1–9.

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Czasopismo Pneumonologia i Alergologia Polska dostęne jest również w Ikamed - księgarnia medyczna

Wydawcą serwisu jest "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl