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Vol 78, No 6 (2010)
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Published online: 2010-10-29
Submitted: 2013-02-22
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Consolidation therapy in advanced non-small cell lung cancer

Renata Duchnowska
Pneumonol Alergol Pol 2010;78(6):439-444.

open access

Vol 78, No 6 (2010)
REVIEWS
Published online: 2010-10-29
Submitted: 2013-02-22

Abstract

Standard management of advanced non-small cell lung cancer includes palliative chemotherapy, but its efficacy is modest. In most cases a few cycles of palliative chemotherapy are administered, as there is no evidence of benefit associated with prolonged treatment. Recently, there is an interest in a new approach including treatment continuation using cytotoxic compounds of proved efficacy in second-line treatment, such as docetaxel and pemetrexed, or targeted agents (erlotinib, gefitinib, cetuximab and bevacizumab). This review presents the current knowledge on this therapeutic strategy including the results of most relevant phase III studies and their metaanalyses.
Pneumonol. Alergol. Pol. 2010; 78, 6: 439-444

Abstract

Standard management of advanced non-small cell lung cancer includes palliative chemotherapy, but its efficacy is modest. In most cases a few cycles of palliative chemotherapy are administered, as there is no evidence of benefit associated with prolonged treatment. Recently, there is an interest in a new approach including treatment continuation using cytotoxic compounds of proved efficacy in second-line treatment, such as docetaxel and pemetrexed, or targeted agents (erlotinib, gefitinib, cetuximab and bevacizumab). This review presents the current knowledge on this therapeutic strategy including the results of most relevant phase III studies and their metaanalyses.
Pneumonol. Alergol. Pol. 2010; 78, 6: 439-444

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Keywords

non-small cell lung cancer; chemotherapy; maintenance therapy; docetaxel; pemetrexed; targeted therapies

About this article
Title

Consolidation therapy in advanced non-small cell lung cancer

Journal

Advances in Respiratory Medicine

Issue

Vol 78, No 6 (2010)

Pages

439-444

Published online

2010-10-29

Bibliographic record

Pneumonol Alergol Pol 2010;78(6):439-444.

Keywords

non-small cell lung cancer
chemotherapy
maintenance therapy
docetaxel
pemetrexed
targeted therapies

Authors

Renata Duchnowska

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