open access

Vol 78, No 6 (2010)
REVIEWS
Published online: 2010-10-29
Submitted: 2013-02-22
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Searching for genes influencing tobacco smoking susceptibility

Alicja Siemińska
Pneumonol Alergol Pol 2010;78(6):432-438.

open access

Vol 78, No 6 (2010)
REVIEWS
Published online: 2010-10-29
Submitted: 2013-02-22

Abstract

Numerous studies indicate genetical background of susceptibility to tobacco smoking. The current review presents new achievements and perspectives in searching for genes involved in tobacco smoking and dependence, which have been described in recent years as a result of the development of molecular techniques. It has been emphasized that tobacco smoking is a complex, polygenic behavior. Presence of multiple gene-gene and gene-environment interactions makes it difficult to find a strong genetic association. The causes of inconsistency in the results of candidate gene association studies, as well as the new perspectives in searching for genetic determinants of tobacco smoking, are also widely discussed. In particular, the focus is on the genome-wide association studies which allow the complex analysis of links between thousands of single nucleotide polymorphisms with smoking phenotypes.
Pneumonol. Alergol. Pol. 2010; 78, 6: 432-438

Abstract

Numerous studies indicate genetical background of susceptibility to tobacco smoking. The current review presents new achievements and perspectives in searching for genes involved in tobacco smoking and dependence, which have been described in recent years as a result of the development of molecular techniques. It has been emphasized that tobacco smoking is a complex, polygenic behavior. Presence of multiple gene-gene and gene-environment interactions makes it difficult to find a strong genetic association. The causes of inconsistency in the results of candidate gene association studies, as well as the new perspectives in searching for genetic determinants of tobacco smoking, are also widely discussed. In particular, the focus is on the genome-wide association studies which allow the complex analysis of links between thousands of single nucleotide polymorphisms with smoking phenotypes.
Pneumonol. Alergol. Pol. 2010; 78, 6: 432-438
Get Citation

Keywords

tobacco smoking; twin studies; linkage analysis; candidate genes; genome-wide association studies

About this article
Title

Searching for genes influencing tobacco smoking susceptibility

Journal

Advances in Respiratory Medicine

Issue

Vol 78, No 6 (2010)

Pages

432-438

Published online

2010-10-29

Bibliographic record

Pneumonol Alergol Pol 2010;78(6):432-438.

Keywords

tobacco smoking
twin studies
linkage analysis
candidate genes
genome-wide association studies

Authors

Alicja Siemińska

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