open access

Vol 79, No 2 (2011)
Published online: 2011-02-24
Submitted: 2013-02-22

Biomarkers in COPD - do we need them?

Halina Batura-Gabryel
Pneumonol Alergol Pol 2011;79(2):144-150.

open access

Vol 79, No 2 (2011)
Published online: 2011-02-24
Submitted: 2013-02-22

Abstract

Chronic obstructive pulmonary disease (COPD) is still a leading cause of death, with a huge socioeconomic impact. Disease is mostly caused by cigarette smoking, characterized by persistent and progressive airway inflammation with pathological changes in the lungs and extrapulmonary and systemic consequences. The standard methods for classifying disease (i.e. forced expiratory volume in 1 second measurement) do not reflect individual characteristics and clinical status of COPD patients, and do not provide information regarding disease activity or the underlying pathologic process. Regarding the clinical evolution and prognosis, several clinical characteristics have been correlated to biomarkers. New strategies for the management of COPD are required, not only for identifying the origin of the exacerbation episodes, but also for phenotyping, assessing prognosis and tailoring treatment for each patient. We have made major gains in biomarker knowledge over the past decade. There are large-scale studies presently underway to identify novel biomarkers in COPD. Results of these investigations may lead to the development of new drugs and other interventions to improve the health outcomes of COPD patients.
Pneumonol. Alergol. Pol. 2011; 79, 2: 144-150

Keywords

COPD; biomarkers; phenotypes

About this article
Title

Biomarkers in COPD - do we need them?

Journal

Advances in Respiratory Medicine

Issue

Vol 79, No 2 (2011)

Pages

144-150

Published online

2011-02-24

Bibliographic record

Pneumonol Alergol Pol 2011;79(2):144-150.

Keywords

COPD
biomarkers
phenotypes

Authors

Halina Batura-Gabryel

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