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Comparison of local and systemic inflammatory markers in patients with community-acquired pneumonia and pneumonia coexisting with lung cancer
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Abstract
Background: The aim of the study was to compare the local and systemic markers of inflammatory processes in patients with community-acquired pneumonia (CAP) and in those with pneumonia coexisting with lung cancer.
Material and methods: Seventeen patients with community-acquired pneumonia (group I), 14 patients with pneumonia and lung cancer (group II), and 24 patients with lung cancer (group III) were enrolled into the study. Sixteen healthy smokers served as a control group (group IV). Concentration of hydrogen peroxide (H2O2), vascular endothelial growth factor (VEGF) and tumor necrosis factor alpha (TNF-α) were measured in exhaled breath condensate (EBC). The levels of VEGF and TNF-α were also measured in serum.
Results: The concentrations of VEGF (317.83 ± 77.78) and TNF-α (1.98 ± 0.13) in EBC were significantly higher in patients with pneumonia and lung cancer as compared to patients with community-acquired pneumonia (VEGF 30.20 ± 6.56; TNF-α 0.31 ± 0.05). Also the level of H2O2 (0.96 ± 0.16) in EBC in patients with pneumonia and lung cancer was elevated in comparison to patients with CAP (0.66 ± 0.09), however the difference was not statistically significant (p > 0.05). The serum concentrations of both studied cytokines were significantly higher in patients with pneumonia (VEGF 1112.62 ± ± 244.38 and TNF-α 2.6 ± 0.48) than in those with pneumonia and lung cancer (VEGF 392.9 ± 78.2; TNF-α 1.6 ± 0.2).
Conclusions: Patients with pneumonia and lung cancer exhibited higher levels of oxidative stress and local inflammatory reactions than those with pneumonia. However, inflammatory markers in serum were significantly lower in patients with pneumonia and lung cancer as compared to those with CAP.
Pneumonol. Alergol. Pol. 2011; 79, 2: 90-98
Abstract
Background: The aim of the study was to compare the local and systemic markers of inflammatory processes in patients with community-acquired pneumonia (CAP) and in those with pneumonia coexisting with lung cancer.
Material and methods: Seventeen patients with community-acquired pneumonia (group I), 14 patients with pneumonia and lung cancer (group II), and 24 patients with lung cancer (group III) were enrolled into the study. Sixteen healthy smokers served as a control group (group IV). Concentration of hydrogen peroxide (H2O2), vascular endothelial growth factor (VEGF) and tumor necrosis factor alpha (TNF-α) were measured in exhaled breath condensate (EBC). The levels of VEGF and TNF-α were also measured in serum.
Results: The concentrations of VEGF (317.83 ± 77.78) and TNF-α (1.98 ± 0.13) in EBC were significantly higher in patients with pneumonia and lung cancer as compared to patients with community-acquired pneumonia (VEGF 30.20 ± 6.56; TNF-α 0.31 ± 0.05). Also the level of H2O2 (0.96 ± 0.16) in EBC in patients with pneumonia and lung cancer was elevated in comparison to patients with CAP (0.66 ± 0.09), however the difference was not statistically significant (p > 0.05). The serum concentrations of both studied cytokines were significantly higher in patients with pneumonia (VEGF 1112.62 ± ± 244.38 and TNF-α 2.6 ± 0.48) than in those with pneumonia and lung cancer (VEGF 392.9 ± 78.2; TNF-α 1.6 ± 0.2).
Conclusions: Patients with pneumonia and lung cancer exhibited higher levels of oxidative stress and local inflammatory reactions than those with pneumonia. However, inflammatory markers in serum were significantly lower in patients with pneumonia and lung cancer as compared to those with CAP.
Pneumonol. Alergol. Pol. 2011; 79, 2: 90-98
Keywords
pneumonia; lung cancer; hydrogen peroxide; vascular endothelial growth factor; tumor necrosis factor alpha
About this articleTitle
Comparison of local and systemic inflammatory markers in patients with community-acquired pneumonia and pneumonia coexisting with lung cancer
Journal
Advances in Respiratory Medicine
Issue
Article type
Research paper
Pages
90-98
Published online
2011-02-24
Bibliographic record
Pneumonol Alergol Pol 2011;79(2):90-98.
Keywords
pneumonia
lung cancer
hydrogen peroxide
vascular endothelial growth factor
tumor necrosis factor alpha
Authors
Agnieszka Urbaniak
Marek Zięba
Anna Zwolińska
Urszula Szkudlarek
Maria Łuczyńska
Krzysztof Noweta
Sylwia Kwiatkowska