open access

Vol 79, No 4 (2011)
CASE REPORTS
Published online: 2011-06-15
Submitted: 2013-02-22
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Bacteriologically confirmed pulmonary tuberculosis in a patient with lymphangioleiomyomatosis accompanying tuberous sclerosis syndrome

Katarzyna Lewandowska, Karina Oniszh, Ewa Augustynowicz-Kopeć, Piotr Radwan-Röhrenschef, Jan Kuś
Pneumonol Alergol Pol 2011;79(4):309-314.

open access

Vol 79, No 4 (2011)
CASE REPORTS
Published online: 2011-06-15
Submitted: 2013-02-22

Abstract

Lymphangioleiomyomatosis (LAM) is a rare disease of unknown origin, that may be sporadic or develop in the course of tuberous sclerosis (TS). Patients do not present immune deficiency, but structural changes in the lung parenchyma (cysts) may encourage various infections, for example tuberculosis. Radiologic findings are often difficult to interpret, because of changes related to LAM itself. We present a young women with a history of TS and LAM, in whom protracting respiratory tract infection was finally diagnosed as tuberculosis. Initial diagnosis was based primarily on clinical signs and symptoms and treatment was started despite the negative result of the sputum microscopy for acid fast bacilli. In the course of treatment the diagnosis was supported by positive tuberculin skin test, interferon-gamma release assay and genetic test for M. tuberculosis in bronchoalveolar lavage fluid, and finally, positive sputum culture in liquid medium.
Pneumonol. Alergol. Pol. 2011; 79, 4: 309–314

Abstract

Lymphangioleiomyomatosis (LAM) is a rare disease of unknown origin, that may be sporadic or develop in the course of tuberous sclerosis (TS). Patients do not present immune deficiency, but structural changes in the lung parenchyma (cysts) may encourage various infections, for example tuberculosis. Radiologic findings are often difficult to interpret, because of changes related to LAM itself. We present a young women with a history of TS and LAM, in whom protracting respiratory tract infection was finally diagnosed as tuberculosis. Initial diagnosis was based primarily on clinical signs and symptoms and treatment was started despite the negative result of the sputum microscopy for acid fast bacilli. In the course of treatment the diagnosis was supported by positive tuberculin skin test, interferon-gamma release assay and genetic test for M. tuberculosis in bronchoalveolar lavage fluid, and finally, positive sputum culture in liquid medium.
Pneumonol. Alergol. Pol. 2011; 79, 4: 309–314
Get Citation

Keywords

lymphangioleiomyomatosis; tuberous sclerosis; tuberculosis; diagnostics

About this article
Title

Bacteriologically confirmed pulmonary tuberculosis in a patient with lymphangioleiomyomatosis accompanying tuberous sclerosis syndrome

Journal

Advances in Respiratory Medicine

Issue

Vol 79, No 4 (2011)

Pages

309-314

Published online

2011-06-15

Bibliographic record

Pneumonol Alergol Pol 2011;79(4):309-314.

Keywords

lymphangioleiomyomatosis
tuberous sclerosis
tuberculosis
diagnostics

Authors

Katarzyna Lewandowska
Karina Oniszh
Ewa Augustynowicz-Kopeć
Piotr Radwan-Röhrenschef
Jan Kuś

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