Vol 79, No 4 (2011)
CASE REPORTS
Published online: 2011-06-15
Submitted: 2013-02-22
Granuloma of epididymis of patient treated with intravesical BCG therapy — complication of BCG therapy or tuberculosis?
Dorota Michałowska-Mitczuk, Sylwia Brzezińska, Ewa Augustynowicz-Kopeć, Renata Langfort
Pneumonol Alergol Pol 2011;79(4):305-308.
Vol 79, No 4 (2011)
CASE REPORTS
Published online: 2011-06-15
Submitted: 2013-02-22
Abstract
We present a case of 72-year old man treated from 2007 for superficial bladder carcinoma. Patient had undergone surgical
intervention for transitional cell carcinoma of the bladder, followed by BCG therapy. Two years later enlarged right testis and
epididymis was observed. A resection was carried out. Histologic examination revealed in epididymis cauda granulomatous
infiltration with eosinophillic necrosis. No bacteriologic tests of resected material were performed. Suspecting BCG infection
or TB patient was referred to the Instititute of Tuberculosis and Lung Diseases in Warsaw for pulmonary evaluation. Chest
X-ray, chest CT scan and bronchoscopy were performed but beside revealing scars in bronchi suggesting a history of TB did
not contribute to the diagnosis. Tuberculin skin test was 21 mm. Diagnosis was determinated by spoligotyping which found
bacille of Mycobacterium tuberculosis in specimen preserved in paraffin block. Tuberculosis of right epididymis and past
pulmonary tuberculosis was diagnosed. Patient was treated with rifampin, isoniazid and pirazynamid.
Pneumonol. Alergol. Pol. 2011; 79, 4: 305–308
Abstract
We present a case of 72-year old man treated from 2007 for superficial bladder carcinoma. Patient had undergone surgical
intervention for transitional cell carcinoma of the bladder, followed by BCG therapy. Two years later enlarged right testis and
epididymis was observed. A resection was carried out. Histologic examination revealed in epididymis cauda granulomatous
infiltration with eosinophillic necrosis. No bacteriologic tests of resected material were performed. Suspecting BCG infection
or TB patient was referred to the Instititute of Tuberculosis and Lung Diseases in Warsaw for pulmonary evaluation. Chest
X-ray, chest CT scan and bronchoscopy were performed but beside revealing scars in bronchi suggesting a history of TB did
not contribute to the diagnosis. Tuberculin skin test was 21 mm. Diagnosis was determinated by spoligotyping which found
bacille of Mycobacterium tuberculosis in specimen preserved in paraffin block. Tuberculosis of right epididymis and past
pulmonary tuberculosis was diagnosed. Patient was treated with rifampin, isoniazid and pirazynamid.
Pneumonol. Alergol. Pol. 2011; 79, 4: 305–308
Keywords
BCG infection; male genital tuberculosis; spoligotyping
Title
Granuloma of epididymis of patient treated with intravesical BCG therapy — complication of BCG therapy or tuberculosis?
Journal
Advances in Respiratory Medicine
Issue
Vol 79, No 4 (2011)
Pages
305-308
Published online
2011-06-15
Bibliographic record
Pneumonol Alergol Pol 2011;79(4):305-308.
Keywords
BCG infection
male genital tuberculosis
spoligotyping
Authors
Dorota Michałowska-Mitczuk
Sylwia Brzezińska
Ewa Augustynowicz-Kopeć
Renata Langfort
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