Granuloma of epididymis of patient treated with intravesical BCG therapy &#8212; complication of BCG therapy or tuberculosis?

Dorota Michałowska-Mitczuk; Sylwia Brzezińska; Ewa Augustynowicz-Kopeć; Renata Langfort

Vol 79, No 4 (2011)

CASE REPORTS

Published online: 2011-06-15

Submitted: 2013-02-22

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Granuloma of epididymis of patient treated with intravesical BCG therapy — complication of BCG therapy or tuberculosis?

Dorota Michałowska-Mitczuk, Sylwia Brzezińska, Ewa Augustynowicz-Kopeć, Renata Langfort

Pneumonol Alergol Pol 2011;79(4):305-308.

Vol 79, No 4 (2011)

CASE REPORTS

Published online: 2011-06-15

Submitted: 2013-02-22

Abstract

We present a case of 72-year old man treated from 2007 for superficial bladder carcinoma. Patient had undergone surgical intervention for transitional cell carcinoma of the bladder, followed by BCG therapy. Two years later enlarged right testis and epididymis was observed. A resection was carried out. Histologic examination revealed in epididymis cauda granulomatous infiltration with eosinophillic necrosis. No bacteriologic tests of resected material were performed. Suspecting BCG infection or TB patient was referred to the Instititute of Tuberculosis and Lung Diseases in Warsaw for pulmonary evaluation. Chest X-ray, chest CT scan and bronchoscopy were performed but beside revealing scars in bronchi suggesting a history of TB did not contribute to the diagnosis. Tuberculin skin test was 21 mm. Diagnosis was determinated by spoligotyping which found bacille of Mycobacterium tuberculosis in specimen preserved in paraffin block. Tuberculosis of right epididymis and past pulmonary tuberculosis was diagnosed. Patient was treated with rifampin, isoniazid and pirazynamid.
Pneumonol. Alergol. Pol. 2011; 79, 4: 305–308