open access

Vol 79, No 4 (2011)
ORIGINAL PAPERS
Published online: 2011-06-15
Submitted: 2013-02-22

Exhaled nitric oxide in patients with esophagitis

Anna Dor-Wojnarowska, Jerzy Liebhart, Marcin Grabowski, Leszek Czapla, Krzysztof Grabowski, Bernard Panaszek
Pneumonol Alergol Pol 2011;79(4):272-277.

open access

Vol 79, No 4 (2011)
ORIGINAL PAPERS
Published online: 2011-06-15
Submitted: 2013-02-22

Abstract

Introduction: Assessment of nitric oxide (NO) concentration in exhaled air is broadly used to monitor the airway inflammation in asthma. High level of NO are also observed in paranasal sinuses and gastrointestinal tract (GT). The intact esopahageal sphincters are responsible for maintain the NO within the GT. It is not known how much the GT and especially esophageal motility disorders can affect the FeNO measurements. The aim of the study was to asses if the gastroesophageal reflux disease has any impact on level of NO in exhaled air in patients who do not suffer from any airway disease.
Material and methods: In 51 patients, in whom asthma, nasal polyps or atopy were excluded, gastroscopy with biopsy was performed. In 13 of them no esophageal pathology was found and they were considered as the control group. In the other 38 patients the esophagitis was diagnosed based on Los Angeles classification.
Results: The concentration of NO in exhaled air in patients with endoscopical gastro-esophageal changes did not differ significantly from the NO concentration in patients without inflammatory changes in stomach and esophagus (p = 0.68). Moreover, the presence of hiatal hernia did not affect the FeNO (p = 0.67). There was also no significant dependence between NO level and infection with Helicobacter pylori (p = 0.18).
Conclusions: The gastroesophageal pathologies did not significantly affect NO concentration in exhaled air.
Pneumonol. Alergol. Pol. 2011; 79, 4: 272–277

Keywords

nitric oxide concentration in exhaled air; FeNO; esophagitis

About this article
Title

Exhaled nitric oxide in patients with esophagitis

Journal

Advances in Respiratory Medicine

Issue

Vol 79, No 4 (2011)

Pages

272-277

Published online

2011-06-15

Bibliographic record

Pneumonol Alergol Pol 2011;79(4):272-277.

Keywords

nitric oxide concentration in exhaled air
FeNO
esophagitis

Authors

Anna Dor-Wojnarowska
Jerzy Liebhart
Marcin Grabowski
Leszek Czapla
Krzysztof Grabowski
Bernard Panaszek

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