Primary immune thrombocytopenia in a patient with sarcoidosis

Marta Dąbrowska; Rafał Krenke; Marta Maskey-Warzęchowska; Piotr Boguradzki; Anna Waszczuk-Gajda; Wiesław Wiktor Jędrzejczak; Paweł Caban; Ryszarda Chazan

Vol 79, No 5 (2011)

Case report

Published online: 2011-08-22

Submitted: 2013-02-22

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Primary immune thrombocytopenia in a patient with sarcoidosis

Marta Dąbrowska, Rafał Krenke, Marta Maskey-Warzęchowska, Piotr Boguradzki, Anna Waszczuk-Gajda, Wiesław Wiktor Jędrzejczak, Paweł Caban, Ryszarda Chazan

Pneumonol Alergol Pol 2011;79(5):371-376.

Vol 79, No 5 (2011)

CASE REPORTS

Published online: 2011-08-22

Submitted: 2013-02-22

Abstract

Sarcoidosis is a disease characterised by a highly variable clinical course. While it may be accompanied by various immune disorders, it is rarely accompanied by disorders of the haematopoietic system. We report a case of sudden-onset primary immune thrombocytopenia co-existing with sarcoidosis. The prevalence of primary immune thrombocytopenia in patients with sarcoidosis is estimated at about 2% and about 1% of patients with thrombocytopenia are diagnosed with sarcoidosis. Three potential pathomechanisms leading to the development of thrombocytopenia in sarcoidosis have been described, namely: (1) the presence of antiplatelet antibodies, (2) presence of epithelioid cell granulomas in the bone marrow and (3) hypersplenism.
Pneumonol. Alergol. Pol. 2011; 79, 5: 371–376

Abstract

Sarcoidosis is a disease characterised by a highly variable clinical course. While it may be accompanied by various immune disorders, it is rarely accompanied by disorders of the haematopoietic system. We report a case of sudden-onset primary immune thrombocytopenia co-existing with sarcoidosis. The prevalence of primary immune thrombocytopenia in patients with sarcoidosis is estimated at about 2% and about 1% of patients with thrombocytopenia are diagnosed with sarcoidosis. Three potential pathomechanisms leading to the development of thrombocytopenia in sarcoidosis have been described, namely: (1) the presence of antiplatelet antibodies, (2) presence of epithelioid cell granulomas in the bone marrow and (3) hypersplenism.
Pneumonol. Alergol. Pol. 2011; 79, 5: 371–376

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Keywords

sarcoidosis; primary immune thrombocytopenia; mediastinal lymph node enlargement; mediastinal lymphadenopathy

About this article

Title

Primary immune thrombocytopenia in a patient with sarcoidosis

Journal

Advances in Respiratory Medicine

Issue

Vol 79, No 5 (2011)

Article type

Case report

Pages

371-376

Published online

2011-08-22

Bibliographic record

Pneumonol Alergol Pol 2011;79(5):371-376.

Keywords

sarcoidosis
primary immune thrombocytopenia
mediastinal lymph node enlargement
mediastinal lymphadenopathy

Authors

Marta Dąbrowska
Rafał Krenke
Marta Maskey-Warzęchowska
Piotr Boguradzki
Anna Waszczuk-Gajda
Wiesław Wiktor Jędrzejczak
Paweł Caban
Ryszarda Chazan