open access

Vol 79, No 6 (2011)
ORIGINAL PAPERS
Published online: 2011-10-25
Submitted: 2013-02-22
Get Citation

Prevalence of latent infection with Mycobacterium tuberculosis in Mazowieckie province using interferon gamma release assay after stimulation with specific antigens ESAT-6 and CFP-10

Jan Kuś, Urszula Demkow, Katarzyna Lewandowska, Maria Korzeniewska-Koseła, Daniel Rabczenko, Izabela Siemion-Szcześniak, Beata Białas-Chromiec, Małgorzata Bychawska, Piotr Sapigórski, Janusz Maciejewski
Pneumonol Alergol Pol 2011;79(6):407-418.

open access

Vol 79, No 6 (2011)
ORIGINAL PAPERS
Published online: 2011-10-25
Submitted: 2013-02-22

Abstract

Introduction: Over 8000 cases of tuberculosis (TB) are diagnosed annually in Poland. People infected with Mycobacterium tuberculosis (MTB) have a risk of active disease around 10% during whole life, the risk is biggest in the first two years after infection. Recognizing infection before TB disease occurred enables prophylaxis against its activation and ceases transmission of infection. Knowledge about proportion of infected people in the population is crucial to predict the number of new cases of active disease.
Material and methods: Prevalence of latent TB infection (LTBI) was tested in 700 healthy adult inhabitants of Mazovia Region in different age groups, using both tuberculin skin test (TST) and interferon gamma release assay (IGRA). Commercial test QuantiFERON®-TB-Gold In Tube (QFT) was used. All participants were mandatory BCG vaccinated according to Polish vaccination schedule.
Results: Twenty three per cent of participants tested positively for QFT, which was significantly less than positive results of TST (50.3%). Prevalence of positive QFT result increased with age, as does the incidence of TB in Poland. Positive QFT was most frequent in the oldest age group (48.8%) and rare in the youngest (7.1%). On the contrary, positive TST occurred more often in younger participants (45%), who rarely suffer from TB. Among people over 60, who have the highest TB incidence rate, only 33.8% tested positively with TST. Concordance between both tests was low, with kappa value 0.198. Prevalence of LTBI defined as positive QFT among health care workers (HCW) was significantly higher than in other participants (32.2% v. 20.4%, p < 0.01). Conclusions: LTBI was diagnosed in 23.3% of tested population of Mazovia
Region. QFT is a better tool for diagnosing LTBI as it shows positive correlation with age, the same as incidence of TB disease does. Concordance between both tests is low. Prevalence of LTBI in HCW is higher than in other participants.
Pneumonol. Alergol. Pol. 2011; 79, 6: 407&#8211;418

Abstract

Introduction: Over 8000 cases of tuberculosis (TB) are diagnosed annually in Poland. People infected with Mycobacterium tuberculosis (MTB) have a risk of active disease around 10% during whole life, the risk is biggest in the first two years after infection. Recognizing infection before TB disease occurred enables prophylaxis against its activation and ceases transmission of infection. Knowledge about proportion of infected people in the population is crucial to predict the number of new cases of active disease.
Material and methods: Prevalence of latent TB infection (LTBI) was tested in 700 healthy adult inhabitants of Mazovia Region in different age groups, using both tuberculin skin test (TST) and interferon gamma release assay (IGRA). Commercial test QuantiFERON®-TB-Gold In Tube (QFT) was used. All participants were mandatory BCG vaccinated according to Polish vaccination schedule.
Results: Twenty three per cent of participants tested positively for QFT, which was significantly less than positive results of TST (50.3%). Prevalence of positive QFT result increased with age, as does the incidence of TB in Poland. Positive QFT was most frequent in the oldest age group (48.8%) and rare in the youngest (7.1%). On the contrary, positive TST occurred more often in younger participants (45%), who rarely suffer from TB. Among people over 60, who have the highest TB incidence rate, only 33.8% tested positively with TST. Concordance between both tests was low, with kappa value 0.198. Prevalence of LTBI defined as positive QFT among health care workers (HCW) was significantly higher than in other participants (32.2% v. 20.4%, p < 0.01). Conclusions: LTBI was diagnosed in 23.3% of tested population of Mazovia
Region. QFT is a better tool for diagnosing LTBI as it shows positive correlation with age, the same as incidence of TB disease does. Concordance between both tests is low. Prevalence of LTBI in HCW is higher than in other participants.
Pneumonol. Alergol. Pol. 2011; 79, 6: 407&#8211;418
Get Citation

Keywords

latent tuberculosis infection; tuberculin skin test; interferon gamma release assay

About this article
Title

Prevalence of latent infection with Mycobacterium tuberculosis in Mazowieckie province using interferon gamma release assay after stimulation with specific antigens ESAT-6 and CFP-10

Journal

Advances in Respiratory Medicine

Issue

Vol 79, No 6 (2011)

Pages

407-418

Published online

2011-10-25

Bibliographic record

Pneumonol Alergol Pol 2011;79(6):407-418.

Keywords

latent tuberculosis infection
tuberculin skin test
interferon gamma release assay

Authors

Jan Kuś
Urszula Demkow
Katarzyna Lewandowska
Maria Korzeniewska-Koseła
Daniel Rabczenko
Izabela Siemion-Szcześniak
Beata Białas-Chromiec
Małgorzata Bychawska
Piotr Sapigórski
Janusz Maciejewski

Important: This website uses cookies.tanya dokter More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Czasopismo Pneumonologia i Alergologia Polska dostęne jest również w Ikamed - księgarnia medyczna

Wydawcą serwisu jest "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl