open access

Vol 80, No 4 (2012)
EDUCATION
Published online: 2012-06-19
Submitted: 2013-02-22

Advances in diagnosis of pulmonary sarcoidosis

Dariusz Ziora, Dariusz Jastrzębski, Łukasz Labus
Pneumonol Alergol Pol 2012;80(4):355-364.

open access

Vol 80, No 4 (2012)
EDUCATION
Published online: 2012-06-19
Submitted: 2013-02-22

Abstract

Sarcoidosis is a systemic granulomatous disease that primarily affects the lung and lymphatic systems of the body. The diagnosis of sarcoidosis is established on the basis of compatible clinical and radiologic findings, supported by histologic evidence in one or more organs of noncaseating epithelioid-cell granulomas. A diagnosis of sarcoidosis is reasonably certain without biopsy in patients who present with Löfgren’s syndrome. In confirmation of sarcoidosis scale lymph node biopsy, endobronchial biopsy, mediastinoscopy, blind tranbronchial needle aspiration and transbronchial lung biopsy or broncho-alveolar lavage were used with diagnostic yields between 60–85%. At present in stage I and II of sarcoidosis the novel technics such as Endoscopic ultrasound-guided, fine-needle aspiration of intrathoracic lymph nodes (EBUS-FNA) and esophageal ultrasound-guided fine-needle aspiration (EUS-FNA) are performed. The combination of these two methods has been reported to provide a diagnostic yield of above 83–90% with about 100% specificity and may obviate the need for mediastinoscopy.

Keywords

sarcoidosis; diagnosis; flexible fiberoptic bronchoscopy; bronchial mucosal biopsy; transbronchial lung biopsy; scalene lymph node biopsy; endobronchial ultrasonography-guided transbronchial needle aspiration; eosophageal ultrasonography-guided trans

About this article
Title

Advances in diagnosis of pulmonary sarcoidosis

Journal

Advances in Respiratory Medicine

Issue

Vol 80, No 4 (2012)

Pages

355-364

Published online

2012-06-19

Bibliographic record

Pneumonol Alergol Pol 2012;80(4):355-364.

Keywords

sarcoidosis
diagnosis
flexible fiberoptic bronchoscopy
bronchial mucosal biopsy
transbronchial lung biopsy
scalene lymph node biopsy
endobronchial ultrasonography-guided transbronchial needle aspiration
eosophageal ultrasonography-guided trans

Authors

Dariusz Ziora
Dariusz Jastrzębski
Łukasz Labus

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