open access

Vol 80, No 5 (2012)
ORIGINAL PAPERS
Published online: 2012-08-27
Submitted: 2013-02-22
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Gefitinib in patients with advanced non-small-cell lung cancer

Magdalena Knetki-Wróblewska, Dariusz M. Kowalski, Katarzyna Zajda, Adam Płużański, Paweł Badurak, Anna Janowicz-Żebrowska, Piotr Jaśkiewicz, Maciej Krzakowski
Pneumonol Alergol Pol 2012;80(5):439-449.

open access

Vol 80, No 5 (2012)
ORIGINAL PAPERS
Published online: 2012-08-27
Submitted: 2013-02-22

Abstract


Introduction: Patients with advanced non-small cell lung cancer (NSCLC) have a very poor prognosis. Individualization of treatment and identification of therapeutic molecular targets may improve outcomes. Gefitinib was introduced recently among several other molecular-targeted drugs of activity in NSCLC. Gefitinib is indicated for patients diagnosed with advanced or disseminated NSCLC with an activating mutation in the EGFR (epidermal growth factor receptor) gene. The paper summarize experience with gefitinib in the Department of Lung and Thoracic Tumors of Maria Sklodowska-Curie Memorial Cancer Centre and Institute in Warsaw.
Material and methods: The group of 11 patients diagnosed with advanced NSCLC and activating mutations in the EGFR gene was analyzed. Patients were treated from April 2010 to April 2011. Tolerability, objective response rate (ORR) and progression free survival (PFS), which was calculated by the Kaplan-Meier method, were assessed.
Results: Median observation time from the start of gefitinib treatment was 14 months (range 4,8–19 months). The rate of one-year survival in this group of patients was 91% (10 patients) with 54% of patients (6 patients) surviving one year without progression of disease. The ORR rate of 82% and median PFS 11.4 months were reached. No treatment-related deaths were reported. Among the complications skin toxicity (82%) and diarrhea (45%) were most frequently observed, in most cases the Common Toxicity Criteria for Adverse Events (CTCAE) first grade.
Conclusions: The results confirm the literature data on the efficacy and safety profile of gefitinib in the treatment of patients with the diagnosis of advanced NSCLC and activating mutation in the EGFR gene.

Abstract


Introduction: Patients with advanced non-small cell lung cancer (NSCLC) have a very poor prognosis. Individualization of treatment and identification of therapeutic molecular targets may improve outcomes. Gefitinib was introduced recently among several other molecular-targeted drugs of activity in NSCLC. Gefitinib is indicated for patients diagnosed with advanced or disseminated NSCLC with an activating mutation in the EGFR (epidermal growth factor receptor) gene. The paper summarize experience with gefitinib in the Department of Lung and Thoracic Tumors of Maria Sklodowska-Curie Memorial Cancer Centre and Institute in Warsaw.
Material and methods: The group of 11 patients diagnosed with advanced NSCLC and activating mutations in the EGFR gene was analyzed. Patients were treated from April 2010 to April 2011. Tolerability, objective response rate (ORR) and progression free survival (PFS), which was calculated by the Kaplan-Meier method, were assessed.
Results: Median observation time from the start of gefitinib treatment was 14 months (range 4,8–19 months). The rate of one-year survival in this group of patients was 91% (10 patients) with 54% of patients (6 patients) surviving one year without progression of disease. The ORR rate of 82% and median PFS 11.4 months were reached. No treatment-related deaths were reported. Among the complications skin toxicity (82%) and diarrhea (45%) were most frequently observed, in most cases the Common Toxicity Criteria for Adverse Events (CTCAE) first grade.
Conclusions: The results confirm the literature data on the efficacy and safety profile of gefitinib in the treatment of patients with the diagnosis of advanced NSCLC and activating mutation in the EGFR gene.
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Keywords

gefitinib; non-small cell lung cancer; EGFR mutation

About this article
Title

Gefitinib in patients with advanced non-small-cell lung cancer

Journal

Advances in Respiratory Medicine

Issue

Vol 80, No 5 (2012)

Pages

439-449

Published online

2012-08-27

Bibliographic record

Pneumonol Alergol Pol 2012;80(5):439-449.

Keywords

gefitinib
non-small cell lung cancer
EGFR mutation

Authors

Magdalena Knetki-Wróblewska
Dariusz M. Kowalski
Katarzyna Zajda
Adam Płużański
Paweł Badurak
Anna Janowicz-Żebrowska
Piotr Jaśkiewicz
Maciej Krzakowski

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