open access

Vol 80, No 6 (2012)
CASE REPORTS
Published online: 2012-10-29
Submitted: 2013-02-22
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Benign pulmonary metastasizing leiomyoma uteri. Case report and review of literature

Elżbieta Radzikowska, Ewa Szczepulska-Wójcik, Renata Langfort, Karina Oniszh, Elżbieta Wiatr
Pneumonol Alergol Pol 2012;80(6):560-561.

open access

Vol 80, No 6 (2012)
CASE REPORTS
Published online: 2012-10-29
Submitted: 2013-02-22

Abstract

Benign metastasizing leiomyoma (BML) is a rare condition in middle-aged women with a history of uterine leiomyomata. It is characterized by the proliferation of, usually multiple, smooth muscle nodules. Approximately 100 cases have been reported in the literature, and the lungs were the most common site of metastases. We report a case of 52-year-old obese woman (BMI 31), hospital worker, smoker, admitted to the hospital with exertional dyspnoea, night sweats, loss of weight, and productive cough. Hysterectomy for a uterine leiomyoma was performed 9 years earlier. In addition, a history of two episodes of superficial vein thrombosis 3 and 2 years before admission was noted. Chest X-ray and subsequently CT chest examinations revealed multiple, non-calcified nodules within the middle and lower parts of both lungs. Specimens obtained by transbronchial biopsy (TBLB) and from open lung biopsy displayed benign muscle cell proliferation compatible with BML. The levels of sex hormones were characteristic for the menopause; therefore, observation was advised. Additionally, Streptococcus pneumoniae was cultured from bronchial washing, and bronchitis was diagnosed. Antibiotics, bronchodilators, and mucolytics were administered, and dyspnoea and cough with expectoration were diminished. Two years later pulmonary lesions have been stable; however, she has put on weight. Subsequently the patient has developed deep vein thrombosis with pulmonary embolism. Anticoagulant treatment was introduced, with some improvement.

Abstract

Benign metastasizing leiomyoma (BML) is a rare condition in middle-aged women with a history of uterine leiomyomata. It is characterized by the proliferation of, usually multiple, smooth muscle nodules. Approximately 100 cases have been reported in the literature, and the lungs were the most common site of metastases. We report a case of 52-year-old obese woman (BMI 31), hospital worker, smoker, admitted to the hospital with exertional dyspnoea, night sweats, loss of weight, and productive cough. Hysterectomy for a uterine leiomyoma was performed 9 years earlier. In addition, a history of two episodes of superficial vein thrombosis 3 and 2 years before admission was noted. Chest X-ray and subsequently CT chest examinations revealed multiple, non-calcified nodules within the middle and lower parts of both lungs. Specimens obtained by transbronchial biopsy (TBLB) and from open lung biopsy displayed benign muscle cell proliferation compatible with BML. The levels of sex hormones were characteristic for the menopause; therefore, observation was advised. Additionally, Streptococcus pneumoniae was cultured from bronchial washing, and bronchitis was diagnosed. Antibiotics, bronchodilators, and mucolytics were administered, and dyspnoea and cough with expectoration were diminished. Two years later pulmonary lesions have been stable; however, she has put on weight. Subsequently the patient has developed deep vein thrombosis with pulmonary embolism. Anticoagulant treatment was introduced, with some improvement.
Get Citation

Keywords

benign metastasizing leiomyoma; BML; pulmonary nodules; round nodules; pulmonary metastases; leiomyoma

About this article
Title

Benign pulmonary metastasizing leiomyoma uteri. Case report and review of literature

Journal

Advances in Respiratory Medicine

Issue

Vol 80, No 6 (2012)

Pages

560-561

Published online

2012-10-29

Bibliographic record

Pneumonol Alergol Pol 2012;80(6):560-561.

Keywords

benign metastasizing leiomyoma
BML
pulmonary nodules
round nodules
pulmonary metastases
leiomyoma

Authors

Elżbieta Radzikowska
Ewa Szczepulska-Wójcik
Renata Langfort
Karina Oniszh
Elżbieta Wiatr

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