open access

Vol 81, No 2 (2013)
REVIEWS
Published online: 2013-02-18
Submitted: 2013-02-22
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The biological role of prokaryotic and eukaryotic N-acetyltransferase

Anna Zabost, Zofia Zwolska, Ewa Augustynowicz-Kopeć
Pneumonol Alergol Pol 2013;81(2):137-144.

open access

Vol 81, No 2 (2013)
REVIEWS
Published online: 2013-02-18
Submitted: 2013-02-22

Abstract

The N-acetyltransferases (NAT; E.C.2.3.1.5) are involved in the metabolism of drugs and environmental toxins. They catalyse the acetyl transfer from acetyl coenzyme A to an aromatic amine, heterocyclic amine, or hydrazine compound. NAT homologues are present in numerous species from bacteria to human. Sequence variations in the human NAT1 and NAT2 result in the production of NAT proteins with variable enzyme activity or stability, leading to slow or rapid acetylation. Therefore, genetic polymorphisms in NAT1 and NAT2 influence drug metabolism and drug-related toxicity. Epidemiological studies suggest that the NAT1 and NAT2 acetylation polymorphisms modify the risk of developing cancers of the urinary bladder, colorectal, breast, head and neck, and lung.

Abstract

The N-acetyltransferases (NAT; E.C.2.3.1.5) are involved in the metabolism of drugs and environmental toxins. They catalyse the acetyl transfer from acetyl coenzyme A to an aromatic amine, heterocyclic amine, or hydrazine compound. NAT homologues are present in numerous species from bacteria to human. Sequence variations in the human NAT1 and NAT2 result in the production of NAT proteins with variable enzyme activity or stability, leading to slow or rapid acetylation. Therefore, genetic polymorphisms in NAT1 and NAT2 influence drug metabolism and drug-related toxicity. Epidemiological studies suggest that the NAT1 and NAT2 acetylation polymorphisms modify the risk of developing cancers of the urinary bladder, colorectal, breast, head and neck, and lung.

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Keywords

acetylation; drug metabolism; genetic polymorphism; neoplastic disease; isoniazid; N-acetyltransferase 1; N-acetyltransferase 2

About this article
Title

The biological role of prokaryotic and eukaryotic N-acetyltransferase

Journal

Advances in Respiratory Medicine

Issue

Vol 81, No 2 (2013)

Pages

137-144

Published online

2013-02-18

Bibliographic record

Pneumonol Alergol Pol 2013;81(2):137-144.

Keywords

acetylation
drug metabolism
genetic polymorphism
neoplastic disease
isoniazid
N-acetyltransferase 1
N-acetyltransferase 2

Authors

Anna Zabost
Zofia Zwolska
Ewa Augustynowicz-Kopeć

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