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Vol 5, No 2 (2006): Polish Palliative Medicine
Artykuły poglądowe
Published online: 2006-05-25
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Opioid-induced hyperalgesia

Sebastiano Mercadante
Advances in Palliative Medicine 2006;5(2):76-81.

open access

Vol 5, No 2 (2006): Polish Palliative Medicine
Artykuły poglądowe
Published online: 2006-05-25

Abstract

Recently it became clear that opioids, besides their role in analgesia, mayalso induce hyperalgesia. Something what in the past was called opioidneurotoxicity. Hyperalgesia, or hypersensitivity to pain stimuli may berelated to well known problems of tolerance to opioids. Hyperalgesia is amajor clinical problem and its recognition and treatment are of paramountimportance. It is believed that uncoupling of opioid receptors from theGi/Go proteins and coupling them to Gs protein changes dramatically activityof opioid receptors. In this article the different aspects of diagnosis andtreatment of hyperalgesia are discussed.

Abstract

Recently it became clear that opioids, besides their role in analgesia, mayalso induce hyperalgesia. Something what in the past was called opioidneurotoxicity. Hyperalgesia, or hypersensitivity to pain stimuli may berelated to well known problems of tolerance to opioids. Hyperalgesia is amajor clinical problem and its recognition and treatment are of paramountimportance. It is believed that uncoupling of opioid receptors from theGi/Go proteins and coupling them to Gs protein changes dramatically activityof opioid receptors. In this article the different aspects of diagnosis andtreatment of hyperalgesia are discussed.
Get Citation

Keywords

opioids; hyperalgesia

About this article
Title

Opioid-induced hyperalgesia

Journal

Advances in Palliative Medicine

Issue

Vol 5, No 2 (2006): Polish Palliative Medicine

Pages

76-81

Published online

2006-05-25

Bibliographic record

Advances in Palliative Medicine 2006;5(2):76-81.

Keywords

opioids
hyperalgesia

Authors

Sebastiano Mercadante

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