open access

Vol 54, No 1 (2023)
Clinical vignette
Submitted: 2022-09-26
Accepted: 2022-12-04
Published online: 2023-02-19
Get Citation

Systemic mastocytosis associated with hematological neoplasm: a diagnostic challenge

Karolina Chromik1, Kinga Boral1, Martyna Dworaczek1, Grzegorz Helbig1
DOI: 10.5603/AHP.a2023.0007
·
Acta Haematol Pol 2023;54(1):46-47.
Affiliations
  1. Department of Hematology and Bone Marrow Transplantation, Medical University of Silesia, Katowice, Poland

open access

Vol 54, No 1 (2023)
CLINICAL VIGNETTE
Submitted: 2022-09-26
Accepted: 2022-12-04
Published online: 2023-02-19

Abstract

Not available

Abstract

Not available
Get Citation

Keywords

systemic mastocytosis, SM-AHN, eosinophilia

About this article
Title

Systemic mastocytosis associated with hematological neoplasm: a diagnostic challenge

Journal

Acta Haematologica Polonica

Issue

Vol 54, No 1 (2023)

Article type

Clinical vignette

Pages

46-47

Published online

2023-02-19

Page views

277

Article views/downloads

64

DOI

10.5603/AHP.a2023.0007

Bibliographic record

Acta Haematol Pol 2023;54(1):46-47.

Keywords

systemic mastocytosis
SM-AHN
eosinophilia

Authors

Karolina Chromik
Kinga Boral
Martyna Dworaczek
Grzegorz Helbig

References (8)
  1. Khoury JD, Solary E, Abla O, et al. The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms. Leukemia. 2022; 36(7): 1703–1719.
  2. Arber DA, Orazi A, Hasserjian R, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016; 127(20): 2391–2405.
  3. Kluin-Nelemans HC, Reiter A, Illerhaus A, et al. Prognostic impact of eosinophils in mastocytosis: analysis of 2350 patients collected in the ECNM Registry. Leukemia. 2020; 34(4): 1090–1101.
  4. Valent P, Orazi A, Savona MR, et al. Proposed diagnostic criteria for classical chronic myelomonocytic leukemia (CMML), CMML variants and pre-CMML conditions. Haematologica. 2019; 104(10): 1935–1949.
  5. Sotlar K, Marafioti T, Griesser H, et al. Detection of c-kit mutation Asp 816 to Val in microdissected bone marrow infiltrates in a case of systemic mastocytosis associated with chronic myelomonocytic leukaemia. Mol Pathol. 2000; 53(4): 188–193.
  6. Jawhar M, Schwaab J, Álvarez-Twose I, et al. MARS: mutation-adjusted risk score for advanced systemic mastocytosis. J Clin Oncol. 2019; 37(31): 2846–2856.
  7. Greiner G, Gurbisz M, Ratzinger F, et al. Digital PCR: a sensitive and precise method for D816V quantification in mastocytosis. Clin Chem. 2018; 64(3): 547–555.
  8. Jawhar M, Schwaab J, Naumann N, et al. Response and progression on midostaurin in advanced systemic mastocytosis: D816V and other molecular markers. Blood. 2017; 130(2): 137–145.

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