open access

Vol 53, No 6 (2022)
Original research article
Submitted: 2022-04-24
Accepted: 2022-09-16
Published online: 2022-11-02
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Relationship between thyroid hormone levels in euthyroid patients before HSCT and time to achieve neutrophil and platelet engraftment: an analytical cross-sectional study

Sepideh Tahsini Tekantapeh1, Nasrin Gholami2, Roya Dolatkhah2, Vahideh Sadra3, Mehdi Derakhshani2, Babak Nejati2, Ali Akbar Movassaghpour2
DOI: 10.5603/AHP.a2022.2051
·
Acta Haematol Pol 2022;53(6):398-406.
Affiliations
  1. Internal Medicine Specialist, Tabriz University of Medical Science, Tabriz, Iran, Islamic Republic Of
  2. Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran, Islamic Republic Of
  3. Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran, Islamic Republic Of

open access

Vol 53, No 6 (2022)
ORIGINAL RESEARCH ARTICLE
Submitted: 2022-04-24
Accepted: 2022-09-16
Published online: 2022-11-02

Abstract

Introduction. The time to reach neutrophil (NE) and platelet engraftment (PE) in hematopoietic stem cell transplantation (HSCT) is one of the most important factors indicating transplantation survival. The aim of this study was to investigate the relationship between thyroid hormone levels before HSCT and the time to achieve NE and PE. Material and methods. The relationship between thyroid hormone levels before HSCT, age, gender, type of HSCT, type of disease and cluster of differentiation 34+ (CD34+) cell count and the number of days to reach NE and PE was examined in 37 clinically and laboratorially euthyroid patients. Results. An odds ratio (OR) of > 6 was observed in the probability of time to NE > 10 days in patients with thyroid-stimulating hormone (TSH) > 2.89 mU/L in the upper normal range (UNR) and male patients, also in the probability of time to PE > 15 days in patients with TSH > 2.89 mU/L in the UNR. Statistically significant p-value and confidence interval were found in the probability of time to NE > 10 days in male patients (OR = 8.58, p-value = 0.036) and time to PE > 15 days in patients with TSH > 2.89 mU/L in the UNR (OR = 14.32, p-value = 0.041). Conclusions. Treatment with low dose levothyroxine can be cautiously recommended to achieve TSH to ≤2.8 mU/L in the lower normal range before performing HSCT in euthyroid patients, which will reduce the times to NE and PE and help earlier discharge of patients.

Abstract

Introduction. The time to reach neutrophil (NE) and platelet engraftment (PE) in hematopoietic stem cell transplantation (HSCT) is one of the most important factors indicating transplantation survival. The aim of this study was to investigate the relationship between thyroid hormone levels before HSCT and the time to achieve NE and PE. Material and methods. The relationship between thyroid hormone levels before HSCT, age, gender, type of HSCT, type of disease and cluster of differentiation 34+ (CD34+) cell count and the number of days to reach NE and PE was examined in 37 clinically and laboratorially euthyroid patients. Results. An odds ratio (OR) of > 6 was observed in the probability of time to NE > 10 days in patients with thyroid-stimulating hormone (TSH) > 2.89 mU/L in the upper normal range (UNR) and male patients, also in the probability of time to PE > 15 days in patients with TSH > 2.89 mU/L in the UNR. Statistically significant p-value and confidence interval were found in the probability of time to NE > 10 days in male patients (OR = 8.58, p-value = 0.036) and time to PE > 15 days in patients with TSH > 2.89 mU/L in the UNR (OR = 14.32, p-value = 0.041). Conclusions. Treatment with low dose levothyroxine can be cautiously recommended to achieve TSH to ≤2.8 mU/L in the lower normal range before performing HSCT in euthyroid patients, which will reduce the times to NE and PE and help earlier discharge of patients.

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Keywords

neutrophil engraftment, platelet engraftment, HSCT, thyroid function, TSH, free T4

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About this article
Title

Relationship between thyroid hormone levels in euthyroid patients before HSCT and time to achieve neutrophil and platelet engraftment: an analytical cross-sectional study

Journal

Acta Haematologica Polonica

Issue

Vol 53, No 6 (2022)

Article type

Original research article

Pages

398-406

Published online

2022-11-02

Page views

555

Article views/downloads

64

DOI

10.5603/AHP.a2022.2051

Bibliographic record

Acta Haematol Pol 2022;53(6):398-406.

Keywords

neutrophil engraftment
platelet engraftment
HSCT
thyroid function
TSH
free T4

Authors

Sepideh Tahsini Tekantapeh
Nasrin Gholami
Roya Dolatkhah
Vahideh Sadra
Mehdi Derakhshani
Babak Nejati
Ali Akbar Movassaghpour

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