open access

Vol 53, No 3 (2022)
Clinical vignette
Submitted: 2022-03-19
Accepted: 2022-04-09
Published online: 2022-06-10
Get Citation

Primary refractory primary mediastinal lymphoma treated with CAR-T: new possibilities and challenges

Krzysztof Żyłka1, Dominik Dytfeld1, Lidia Gil1
DOI: 10.5603/AHP.a2022.0026
·
Acta Haematol Pol 2022;53(3):215-217.
Affiliations
  1. Department of Hematology and Bone Marrow Transplantation, University of Medical Sciences, Poznań, Poland

open access

Vol 53, No 3 (2022)
CLINICAL VIGNETTE
Submitted: 2022-03-19
Accepted: 2022-04-09
Published online: 2022-06-10

Abstract

Not available

Abstract

Not available
Get Citation

Keywords

CAR-T; PMBCL; axicabtagene cyloleucel; axi-cel; CRS; ICANS; B-NHL; LBCL; allo-HCT

About this article
Title

Primary refractory primary mediastinal lymphoma treated with CAR-T: new possibilities and challenges

Journal

Acta Haematologica Polonica

Issue

Vol 53, No 3 (2022)

Article type

Clinical vignette

Pages

215-217

Published online

2022-06-10

Page views

2094

Article views/downloads

199

DOI

10.5603/AHP.a2022.0026

Bibliographic record

Acta Haematol Pol 2022;53(3):215-217.

Keywords

CAR-T
PMBCL
axicabtagene cyloleucel
axi-cel
CRS
ICANS
B-NHL
LBCL
allo-HCT

Authors

Krzysztof Żyłka
Dominik Dytfeld
Lidia Gil

References (10)
  1. Lees C, Keane C, Gandhi MK, et al. Biology and therapy of primary mediastinal B-cell lymphoma: current status and future directions. Br J Haematol. 2019; 185(1): 25–41.
  2. Crump M, Neelapu S, Farooq U, et al. Outcomes in refractory diffuse large B-cell lymphoma: results from the international SCHOLAR-1 study. Blood. 2017; 130(16): 1800–1808.
  3. Neelapu SS, Locke FL, Bartlett NL, et al. Axicabtagene ciloleucel CAR T-cell therapy in refractory large B-cell lymphoma. N Engl J Med. 2017; 377(26): 2531–2544.
  4. Lee DW, Santomasso BD, Locke FL, et al. ASTCT consensus grading for cytokine release syndrome and neurologic toxicity associated with immune effector cells. Biol Blood Marrow Transplant. 2019; 25(4): 625–638.
  5. Gil L, Łojko-Dankowska A, Matuszak M, et al. CAR-T cell therapy — toxicity and its management. Acta Haematol Pol. 2020; 51(1): 6–10.
  6. Jain T, Bar M, Kansagra AJ, et al. Use of chimeric antigen receptor T cell therapy in clinical practice for relapsed/refractory aggressive B cell non-Hodgkin lymphoma: an Expert Panel Opinion from the American Society for Transplantation and Cellular Therapy. Biol Blood Marrow Transplant. 2019; 25(12): 2305–2321.
  7. Girmenia C, Raiola AM, Piciocchi A, et al. Incidence and outcome of invasive fungal diseases after allogeneic stem cell transplantation: a prospective study of the Gruppo Italiano Trapianto Midollo Osseo (GITMO). Biol Blood Marrow Transplant. 2014; 20(6): 872–880.
  8. Al Zaki A, Feng L, Watson G, et al. Day 30 SUVmax predicts progression in patients with lymphoma achieving PR/SD after CAR T-cell therapy. Blood Adv. 2022; 6(9): 2867–2871.
  9. Figura NB, Robinson TJ, Sim AJ, et al. Patterns and predictors of failure in recurrent or refractory large B-cell lymphomas after chimeric antigen receptor T-cell therapy. Int J Radiat Oncol Biol Phys. 2021; 111(5): 1145–1154.
  10. Hayden PJ, Roddie C, Bader P, et al. Management of adults and children receiving CAR T-cell therapy: 2021 best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) and the European Haematology Association (EHA). Ann Oncol. 2022; 33(3): 259–275.

Regulations

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By VM Media Group sp. z o.o., Grupa Via Medica, ul. Świętokrzyska 73, 80–180 Gdańsk, Poland
phone: +48 58 320 94 94, fax: +48 58 320 94 60, e-mail: viamedica@viamedica.pl