open access

Vol 53, No 5 (2022)
Original research article
Submitted: 2022-02-22
Accepted: 2022-04-24
Published online: 2022-10-03
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Thrombocytopenia in critically ill patients: single center data analysis

Magdalena Dziech1, Katarzyna Musiałkiewicz2, Michał P. Pluta2, Łukasz J. Krzych2
DOI: 10.5603/AHP.a2022.2045
·
Acta Haematol Pol 2022;53(5):345-349.
Affiliations
  1. Students’ Scientific Society, Department of Anaesthesiology and Intensive Care, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland
  2. Department of Anaesthesiology and Intensive Care, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland

open access

Vol 53, No 5 (2022)
ORIGINAL RESEARCH ARTICLE
Submitted: 2022-02-22
Accepted: 2022-04-24
Published online: 2022-10-03

Abstract

Introduction: Thrombocytopenia (TP) is one of the most frequent abnormalities of hemostasis found in laboratory tests in critically ill patients. The aim of this study was to determine the frequency and most probable causes of TP in patients hospitalized in the Intensive Care Unit (ICU).

Material and methods: The documentation of all patients hospitalized in 2019 was analyzed retrospectively in the ICU of the university hospital. Patients diagnosed with TP at admission to the ward or during hospitalization were identified. Potential factors influencing the platelet count were analyzed.

Results: During the analyzed period, 291 patients were hospitalized. In 93 patients (32%), TP was diagnosed, including 61 patients at admission (21%), and the remaining 32 patients (11%) during hospitalization. Patients with TP had higher SAPS II, APACHE II and SOFA scores than patients without TP (p <0.001 for all). Mortality in patients with TP was twice as high as in patients without TP (58% vs. 29%, p <0.001). In 18 patients (6%), only one cause of TP was potentially identified, while in 39 patients (13%), four or more factors that could potentially cause TP were identified.

Conclusions: Thrombocytopenia is a relatively common problem in the critically ill population, but due to the challenges in differential diagnosis, a reliable assessment of the causes of its occurrence is difficult.

Abstract

Introduction: Thrombocytopenia (TP) is one of the most frequent abnormalities of hemostasis found in laboratory tests in critically ill patients. The aim of this study was to determine the frequency and most probable causes of TP in patients hospitalized in the Intensive Care Unit (ICU).

Material and methods: The documentation of all patients hospitalized in 2019 was analyzed retrospectively in the ICU of the university hospital. Patients diagnosed with TP at admission to the ward or during hospitalization were identified. Potential factors influencing the platelet count were analyzed.

Results: During the analyzed period, 291 patients were hospitalized. In 93 patients (32%), TP was diagnosed, including 61 patients at admission (21%), and the remaining 32 patients (11%) during hospitalization. Patients with TP had higher SAPS II, APACHE II and SOFA scores than patients without TP (p <0.001 for all). Mortality in patients with TP was twice as high as in patients without TP (58% vs. 29%, p <0.001). In 18 patients (6%), only one cause of TP was potentially identified, while in 39 patients (13%), four or more factors that could potentially cause TP were identified.

Conclusions: Thrombocytopenia is a relatively common problem in the critically ill population, but due to the challenges in differential diagnosis, a reliable assessment of the causes of its occurrence is difficult.

Get Citation

Keywords

thrombocytopenia, critical care, intensive care unit

About this article
Title

Thrombocytopenia in critically ill patients: single center data analysis

Journal

Acta Haematologica Polonica

Issue

Vol 53, No 5 (2022)

Article type

Original research article

Pages

345-349

Published online

2022-10-03

Page views

911

Article views/downloads

84

DOI

10.5603/AHP.a2022.2045

Bibliographic record

Acta Haematol Pol 2022;53(5):345-349.

Keywords

thrombocytopenia
critical care
intensive care unit

Authors

Magdalena Dziech
Katarzyna Musiałkiewicz
Michał P. Pluta
Łukasz J. Krzych

References (11)
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  7. World Healt Organization. ICD-10. International Statistical Classification of Diseases and Related Health Problems. 10th revision. Volume 1. Tabular List. Fifth edition. WHO Press, Geneva 2016.
  8. Krzych ŁJ, Nowacka E, Knapik P. Heparin-induced thrombocytopenia. Anaesthesiol Intensive Ther. 2015; 47(1): 63–76.
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  10. Witosz K, Wojnarowicz O, Krzych ŁJ. Iatrogenic blood loss due to daily laboratory testing and the risk of subsequent anaemia in intensive care unit patients: case series. Acta Biochim Pol. 2021; 68(1): 135–138.
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