open access

Vol 53, No 6 (2022)
Original research article
Submitted: 2021-11-05
Accepted: 2022-05-23
Published online: 2022-10-02
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Prognostic value of B-cell maturation antigen, CD56 expression and neutrophil lymphocyte ratio in patients with multiple myeloma

Mona Saied Fadilah1, Hala Kassem Sultan1, Maha Mohamed Adel El-Gammal1, Ola Ali Balbaa1, Amel Ali El-Naggar1
DOI: 10.5603/AHP.a2022.2046
·
Acta Haematol Pol 2022;53(6):386-391.
Affiliations
  1. Department of Hematology, Medical Research Institute, Alexandria University, Alexandria, Egypt

open access

Vol 53, No 6 (2022)
ORIGINAL RESEARCH ARTICLE
Submitted: 2021-11-05
Accepted: 2022-05-23
Published online: 2022-10-02

Abstract

Introduction: B-cell maturation antigen (BCMA) plays a critical role in regulating B-cell proliferation and differentiation into plasma cells. CD56 is involved in the adhesion of myeloma cells to the bone marrow matrix. Thus, lack of CD56 expression is associated with a higher incidence of extramedullary disease. An elevated neutrophil-lymphocyte ratio (NLR) has been recognized as a poor prognostic factor in various hematological malignancies.
The aim of this study was to evaluate the role of BCMA, CD56 and NLR as novel prognostic markers in multiple myeloma (MM).
Material and methods: The study included 80 subjects, 40 MM patients, and 40 normal healthy age- and sex-matched controls. BCMA was analyzed by enzyme-linked immune sorbent assay. Flow cytometry was used for the determination of CD56 expression. NLR was calculated from the complete blood count differential count. All patients received six cycles of bortezomib, cyclophosphamide and dexamethasone (VCD). Treatment outcome was assessed and progression-free survival (PFS) was estimated using Kaplan-Meier survival analysis.
Results: Patients who achieved complete remission showed lower BCMA levels, positive CD56 expression, and lower NLR. Moreover, higher BCMA levels and CD56 negative expression were significantly associated with shorter PFS.
Conclusions: Our study emphasizes the importance of BCMA, CD56 and   NLR to predict the clinical outcome in MM patients. This could help in better risk stratification and tailored clinical management of MM patients.

Abstract

Introduction: B-cell maturation antigen (BCMA) plays a critical role in regulating B-cell proliferation and differentiation into plasma cells. CD56 is involved in the adhesion of myeloma cells to the bone marrow matrix. Thus, lack of CD56 expression is associated with a higher incidence of extramedullary disease. An elevated neutrophil-lymphocyte ratio (NLR) has been recognized as a poor prognostic factor in various hematological malignancies.
The aim of this study was to evaluate the role of BCMA, CD56 and NLR as novel prognostic markers in multiple myeloma (MM).
Material and methods: The study included 80 subjects, 40 MM patients, and 40 normal healthy age- and sex-matched controls. BCMA was analyzed by enzyme-linked immune sorbent assay. Flow cytometry was used for the determination of CD56 expression. NLR was calculated from the complete blood count differential count. All patients received six cycles of bortezomib, cyclophosphamide and dexamethasone (VCD). Treatment outcome was assessed and progression-free survival (PFS) was estimated using Kaplan-Meier survival analysis.
Results: Patients who achieved complete remission showed lower BCMA levels, positive CD56 expression, and lower NLR. Moreover, higher BCMA levels and CD56 negative expression were significantly associated with shorter PFS.
Conclusions: Our study emphasizes the importance of BCMA, CD56 and   NLR to predict the clinical outcome in MM patients. This could help in better risk stratification and tailored clinical management of MM patients.

Get Citation

Keywords

BCMA, CD56, neutrophil-lymphocyte ratio, myeloma

About this article
Title

Prognostic value of B-cell maturation antigen, CD56 expression and neutrophil lymphocyte ratio in patients with multiple myeloma

Journal

Acta Haematologica Polonica

Issue

Vol 53, No 6 (2022)

Article type

Original research article

Pages

386-391

Published online

2022-10-02

Page views

576

Article views/downloads

75

DOI

10.5603/AHP.a2022.2046

Bibliographic record

Acta Haematol Pol 2022;53(6):386-391.

Keywords

BCMA
CD56
neutrophil-lymphocyte ratio
myeloma

Authors

Mona Saied Fadilah
Hala Kassem Sultan
Maha Mohamed Adel El-Gammal
Ola Ali Balbaa
Amel Ali El-Naggar

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