open access

Vol 53, No 2 (2022)
Guidelines / Expert consensus
Submitted: 2021-10-08
Accepted: 2021-11-25
Published online: 2022-03-07
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Treatment recommendations developed by MDS experts of the Polish Adult Leukemia Group (PALG) for management of myelodysplastic syndromes (MDSs) and other MDS-related conditions in Poland for 2021

Krzysztof Mądry1, Bożena Katarzyna Budziszewska2, Karol Lis1, Joanna Drozd-Sokołowska1, Bartłomiej Pogłódek3, Rafał Machowicz1, Edyta Subocz4, Katarzyna Wisniewska-Piąty5, Tomasz Wróbel6, Jan Maciej Zaucha7, Ewa Zarzycka7, Ewa Karakulska-Prystupiuk1, Lidia Gil8, Aleksandra Butrym9, Agnieszka Tomaszewska1, Grzegorz Władysław Basak1, Anna Waszczuk-Gajda1, Agnieszka Pluta10, Paweł Szwedyk11, Małgorzata Jarmuż-Szymczak8, Jagoda Rytel1, Jadwiga Dwilewicz-Trojaczek1
DOI: 10.5603/AHP.a2022.0009
·
Acta Haematol Pol 2022;53(2):75-93.
Affiliations
  1. Department of Hematology, Transplantation and Internal Medicine, Medical University of Warsaw, Poland
  2. Department of Hematology, Institute of Hematology and Transfusiology, Warsaw, Poland
  3. Department of Hematology, Jagiellonian University, Kraków
  4. Department of Hematology, Warmian-Masurian Cancer Center of the Ministry of the Interior and Administration’s Hospital, Olsztyn
  5. Department of Hematology and Bone Marrow Transplantation, Medical University of Silesia, Katowice
  6. Department of Hematology, Blood Neoplasms and Bone Marrow Transplantation, Wrocław Medical University, Wrocław, Poland
  7. Department of Hematology and Transplantology, Medical University of Gdańsk, Gdańsk, Poland
  8. Department of Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, Poznań, Poland
  9. Department of Cancer Prevention and Therapy, Wroclaw Medical University, Wroclaw, Poland
  10. Department of Hematology, Medical University, Lodz, Poland
  11. Department of Hematology, Ludwik Rydygier Hospital, Krakow, Poland

open access

Vol 53, No 2 (2022)
EXPERT GUIDELINES
Submitted: 2021-10-08
Accepted: 2021-11-25
Published online: 2022-03-07

Abstract

Myelodysplastic syndromes (MDS) comprise a heterogeneous group of malignant hematopoietic stem cell disorders that are characterized by ineffective blood cell production and a variable risk of transformation into acute myeloid leukemia. In recent years, significant progress in MDS biological research has allowed the addition of new drugs to the few existing therapeutic options.

This article presents the recommendations of MDS experts of the Polish Adult Leukemia Group for the treatment of myelodysplastic syndromes, and for the management of conditions that are particularly common in patients with MDS i.e. infections, iron overload, and disease recurrence after hematopoietic cell transplantation. The aim of this study was to present a clear therapeutic algorithm to facilitate decision-making in everyday practice.

Abstract

Myelodysplastic syndromes (MDS) comprise a heterogeneous group of malignant hematopoietic stem cell disorders that are characterized by ineffective blood cell production and a variable risk of transformation into acute myeloid leukemia. In recent years, significant progress in MDS biological research has allowed the addition of new drugs to the few existing therapeutic options.

This article presents the recommendations of MDS experts of the Polish Adult Leukemia Group for the treatment of myelodysplastic syndromes, and for the management of conditions that are particularly common in patients with MDS i.e. infections, iron overload, and disease recurrence after hematopoietic cell transplantation. The aim of this study was to present a clear therapeutic algorithm to facilitate decision-making in everyday practice.

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Keywords

myelodysplastic syndromes, treatment, recommendations

About this article
Title

Treatment recommendations developed by MDS experts of the Polish Adult Leukemia Group (PALG) for management of myelodysplastic syndromes (MDSs) and other MDS-related conditions in Poland for 2021

Journal

Acta Haematologica Polonica

Issue

Vol 53, No 2 (2022)

Article type

Guidelines / Expert consensus

Pages

75-93

Published online

2022-03-07

Page views

218

Article views/downloads

58

DOI

10.5603/AHP.a2022.0009

Bibliographic record

Acta Haematol Pol 2022;53(2):75-93.

Keywords

myelodysplastic syndromes
treatment
recommendations

Authors

Krzysztof Mądry
Bożena Katarzyna Budziszewska
Karol Lis
Joanna Drozd-Sokołowska
Bartłomiej Pogłódek
Rafał Machowicz
Edyta Subocz
Katarzyna Wisniewska-Piąty
Tomasz Wróbel
Jan Maciej Zaucha
Ewa Zarzycka
Ewa Karakulska-Prystupiuk
Lidia Gil
Aleksandra Butrym
Agnieszka Tomaszewska
Grzegorz Władysław Basak
Anna Waszczuk-Gajda
Agnieszka Pluta
Paweł Szwedyk
Małgorzata Jarmuż-Szymczak
Jagoda Rytel
Jadwiga Dwilewicz-Trojaczek

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