open access

Vol 52, No 6 (2021)
Original research article
Submitted: 2021-09-15
Accepted: 2021-09-15
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Ferritin and transferrin saturation cannot be used to diagnose iron-deficiency anemia in critically ill patients

Piotr F. Czempik1, Michał P. Pluta1, Łukasz J. Krzych1
DOI: 10.5603/AHP.2021.0091
·
Acta Haematol Pol 2021;52(6):566-570.
Affiliations
  1. Department of Anaesthesiology and Intensive Care, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland

open access

Vol 52, No 6 (2021)
ORIGINAL RESEARCH ARTICLE
Submitted: 2021-09-15
Accepted: 2021-09-15

Abstract

Abstract Introduction: Iron-deficiency anaemia (IDA) is the most common anaemia globally. The frequency of IDA among critically ill patients is not known. The aim of our study was to analyse performance of standard iron metabolism parameters in diagnosis of IDA in the critically ill. Material and methods: We performed a retrospective analysis of consecutive anaemic patients admitted to the intensive care unit. Based on various cut-off values for ferritin and/or transferrin saturation (TfS), we determined the incidence of IDA. Results: The population consisted of 27 (53%) men and 24 (47%) women. The median haemoglobin concentration was well 96 [interquartile range (IQR 87–109)] g/L. The studied population had markedly increased concentration of C-reactive protein [119 (IQR 44–196) mg/L], ferritin [686 (385–1114) µg/L], whereas iron concentration and TfS were below reference value. Depending on cut-off value chosen, IDA could be diagnosed in between 7.8 (ferritin < 100 µg/L +TfS < 20%) and 56.9 % (TfS < 20%) of patients. Conclusions: Ferritin and transferrin saturation cannot be used for precise diagnosis of IDA caused by absolute or functional iron deficiency in the critically ill.

Abstract

Abstract Introduction: Iron-deficiency anaemia (IDA) is the most common anaemia globally. The frequency of IDA among critically ill patients is not known. The aim of our study was to analyse performance of standard iron metabolism parameters in diagnosis of IDA in the critically ill. Material and methods: We performed a retrospective analysis of consecutive anaemic patients admitted to the intensive care unit. Based on various cut-off values for ferritin and/or transferrin saturation (TfS), we determined the incidence of IDA. Results: The population consisted of 27 (53%) men and 24 (47%) women. The median haemoglobin concentration was well 96 [interquartile range (IQR 87–109)] g/L. The studied population had markedly increased concentration of C-reactive protein [119 (IQR 44–196) mg/L], ferritin [686 (385–1114) µg/L], whereas iron concentration and TfS were below reference value. Depending on cut-off value chosen, IDA could be diagnosed in between 7.8 (ferritin < 100 µg/L +TfS < 20%) and 56.9 % (TfS < 20%) of patients. Conclusions: Ferritin and transferrin saturation cannot be used for precise diagnosis of IDA caused by absolute or functional iron deficiency in the critically ill.

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Keywords

ferritin, intensive care unit, iron-deficiency anaemia, transferrin saturation

About this article
Title

Ferritin and transferrin saturation cannot be used to diagnose iron-deficiency anemia in critically ill patients

Journal

Acta Haematologica Polonica

Issue

Vol 52, No 6 (2021)

Article type

Original research article

Pages

566-570

Page views

3176

Article views/downloads

272

DOI

10.5603/AHP.2021.0091

Bibliographic record

Acta Haematol Pol 2021;52(6):566-570.

Keywords

ferritin
intensive care unit
iron-deficiency anaemia
transferrin saturation

Authors

Piotr F. Czempik
Michał P. Pluta
Łukasz J. Krzych

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