open access

Vol 53, No 1 (2022)
Guidelines / Expert consensus
Submitted: 2021-09-19
Accepted: 2021-10-26
Published online: 2021-12-31
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Diagnosis of myelodysplastic syndromes in Poland: Polish Adult Leukemia Group (PALG) 2021 recommendations

Krzysztof Mądry1, Joanna Drozd-Sokołowska1, Karol Lis1, Bożena Katarzyna Budziszewska2, Bartłomiej Pogłódek3, Rafał Machowicz1, Edyta Subocz4, Katarzyna Wiśniewska-Piąty5, Tomasz Wróbel6, Jan Maciej Zaucha7, Ewa Zarzycka7, Olga Haus8, Ewa Karakulska-Prystupiuk1, Lidia Gil9, Aleksandra Butrym10, Agnieszka Tomaszewska1, Grzegorz W. Basak1, Anna Waszczuk-Gajda1, Agnieszka Pluta11, Paweł Szwedyk12, Małgorzata Jarmuż-Szymczak9, Jagoda Rytel1, Jadwiga Dwilewicz-Trojaczek1
DOI: 10.5603/AHP.a2022.0001
·
Acta Haematol Pol 2022;53(1):3-18.
Affiliations
  1. Department of Hematology, Transplantation and Internal Medicine, Medical University of Warsaw, Poland
  2. Department of Hematology, Institute of Hematology and Transfusiology, Warsaw, Poland
  3. Department of Hematology, Jagiellonian University, Collegium Medicum, Kraków, Poland
  4. Department of Hematology, Warmian-Masurian Cancer Center of the Ministry of the Interior and Administration’s Hospital, Olsztyn
  5. Department of Hematology and Bone Marrow Transplantation, Medical University of Silesia, Katowice
  6. Department of Hematology, Blood Neoplasms and Bone Marrow Transplantation, Wrocław Medical University, Wrocław, Poland
  7. Department of Hematology and Transplantology, Medical University of Gdańsk, Gdańsk, Poland
  8. Department of Clinical Genetics, Collegium Medicum Bydgoszcz, Nicolaus Copernicus University, Torun
  9. Department of Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, Poznań, Poland
  10. Department of Cancer Prevention and Therapy, Wroclaw Medical University, Wrocław, Poland
  11. Department of Hematology, Medical University of Lodz, Łódź, Poland
  12. Department of Hematology, Ludwik Rydygier Hospital, Krakow, Poland

open access

Vol 53, No 1 (2022)
EXPERT GUIDELINES
Submitted: 2021-09-19
Accepted: 2021-10-26
Published online: 2021-12-31

Abstract

Myelodysplastic syndromes (MDS) are a heterogeneous group of neoplastic diseases of the hematopoietic cells manifested by ineffective hematopoiesis and a tendency to transform into acute myeloid leukemia. MDS should be considered in the differential diagnosis of cytopenia, especially in the elderly. This article presents the recommendations of MDS experts of the Polish Adult Leukemia Group (PALG) for the diagnosis of myelodysplastic syndromes. We present current classifications and prognostic indices, as well as diagnostic examinations recommended for MDS: cytological, histopathological, immunophenotypic, cytogenetic and molecular tests. The aim of the study is to implement up-to-date knowledge about myelodysplastic syndromes into routine clinical practice, from the diagnosis of cytopenia to the specific diagnosis and prognosis in MDS patients.  

Abstract

Myelodysplastic syndromes (MDS) are a heterogeneous group of neoplastic diseases of the hematopoietic cells manifested by ineffective hematopoiesis and a tendency to transform into acute myeloid leukemia. MDS should be considered in the differential diagnosis of cytopenia, especially in the elderly. This article presents the recommendations of MDS experts of the Polish Adult Leukemia Group (PALG) for the diagnosis of myelodysplastic syndromes. We present current classifications and prognostic indices, as well as diagnostic examinations recommended for MDS: cytological, histopathological, immunophenotypic, cytogenetic and molecular tests. The aim of the study is to implement up-to-date knowledge about myelodysplastic syndromes into routine clinical practice, from the diagnosis of cytopenia to the specific diagnosis and prognosis in MDS patients.  
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Keywords

myelodysplastic syndromes, diagnosis, recommendations

About this article
Title

Diagnosis of myelodysplastic syndromes in Poland: Polish Adult Leukemia Group (PALG) 2021 recommendations

Journal

Acta Haematologica Polonica

Issue

Vol 53, No 1 (2022)

Article type

Guidelines / Expert consensus

Pages

3-18

Published online

2021-12-31

Page views

977

Article views/downloads

124

DOI

10.5603/AHP.a2022.0001

Bibliographic record

Acta Haematol Pol 2022;53(1):3-18.

Keywords

myelodysplastic syndromes
diagnosis
recommendations

Authors

Krzysztof Mądry
Joanna Drozd-Sokołowska
Karol Lis
Bożena Katarzyna Budziszewska
Bartłomiej Pogłódek
Rafał Machowicz
Edyta Subocz
Katarzyna Wiśniewska-Piąty
Tomasz Wróbel
Jan Maciej Zaucha
Ewa Zarzycka
Olga Haus
Ewa Karakulska-Prystupiuk
Lidia Gil
Aleksandra Butrym
Agnieszka Tomaszewska
Grzegorz W. Basak
Anna Waszczuk-Gajda
Agnieszka Pluta
Paweł Szwedyk
Małgorzata Jarmuż-Szymczak
Jagoda Rytel
Jadwiga Dwilewicz-Trojaczek

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